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- W2078442714 abstract "Three days after withdrawal of maintenance treatment, peak expiratory flow rate (PEFR) was measured in 38 asthmatic children every four hours during 24 hours on three consecutive days. In all children a circadian rhythm, with a nocturnal fall in PEFR existed. The interindividual amplitude varied from 2 to 65%. Two groups of 9 patients each, were selected from the total study population based on a difference in PEFR values between 16.00 and 04.00 hours of more then 20% or less then 15% on three study days. The remaining children did not fit in both subgroups because the 16.00 and 04.00 hour difference in PEFR values was not persistent. The clinical data of this group, however, were comparable with both subgroups. In the group with a 16.00 - 04.00 hours difference of more then 20% (mean ± SD: 31.5±8.5) both the mean PEFR value and the PEFR value measured at 04.00 hours on day 6 was significantly decreased as compared to the values obtained on day 4. Moreover the amplitude of the PEFR still increased significantly from day 4 to day 6. In the group with 16.00 - 04.00 hours difference of less then 15% (mean ± SD: 6.4 ± 2.7) no increase in amplitude and decrease in mean PEFR values during day 4 and day 6 were observed. With regard to FEV1/FEV1 predicted, PC20 Histamine and skintests no significant differences were observed between both subgroups. In retrospect the group of children with the large amplitude seems to be more inhaled steroid dependent." @default.
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- W2078442714 date "1986-10-01" @default.
- W2078442714 modified "2023-09-23" @default.
- W2078442714 title "49 CIRGADIAN PULMONARY RHYTHMS IN ASTHMATIC CHILDREN AFTER WITHDRAWAL OF MEDICATION" @default.
- W2078442714 doi "https://doi.org/10.1203/00006450-198610000-00103" @default.
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