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- W2078444871 abstract "A case of lefetamine abuse (0.9-1.8 g/day in 15-30 i.m. divided doses) is reported. In this patient, the administration of naloxone precipitated a mild opiate-like withdrawal syndrome, characterized by mydriasis, piloerection, yawning and a slight increase of blood pressure. The complete withdrawal of lefetamine, substituted by a placebo regimen, aggravated these symptoms. Furthermore, experimental results showed that lefetamine induced a naloxone-reversible inhibition of the guinea-pig ileum contractile response to electric field stimulation, and that naloxone pretreatment of mice prevented lefetamine antinociceptive activity in the hot-plate test. The clinical and experimental findings suggest that lefetamine has an opiate-like activity." @default.
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- W2078444871 date "1984-09-01" @default.
- W2078444871 modified "2023-09-24" @default.
- W2078444871 title "Clinical and experimental evidence of an opiate-like activity of lefetamine" @default.
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- W2078444871 doi "https://doi.org/10.1016/s0031-6989(84)80028-4" @default.
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