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- W2078446890 endingPage "a012591" @default.
- W2078446890 startingPage "a012591" @default.
- W2078446890 abstract "Nucleotide excision repair (NER) has allowed bacteria to flourish in many different niches around the globe that inflict harsh environmental damage to their genetic material. NER is remarkable because of its diverse substrate repertoire, which differs greatly in chemical composition and structure. Recent advances in structural biology and single-molecule studies have given great insight into the structure and function of NER components. This ensemble of proteins orchestrates faithful removal of toxic DNA lesions through a multistep process. The damaged nucleotide is recognized by dynamic probing of the DNA structure that is then verified and marked for dual incisions followed by excision of the damage and surrounding nucleotides. The opposite DNA strand serves as a template for repair, which is completed after resynthesis and ligation." @default.
- W2078446890 created "2016-06-24" @default.
- W2078446890 creator A5013701746 @default.
- W2078446890 creator A5029478690 @default.
- W2078446890 creator A5055919829 @default.
- W2078446890 date "2013-03-01" @default.
- W2078446890 modified "2023-10-10" @default.
- W2078446890 title "Prokaryotic Nucleotide Excision Repair" @default.
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