FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078447546> ?p ?o ?g. }

• W2078447546 endingPage "54" @default.
• W2078447546 startingPage "46" @default.
• W2078447546 abstract "A clonal cell line from rat osteosarcoma was found to possess parathyroid hormone and isoproterenol sensitive adenylate cyclase. This study examines the relationship between the two hormones and triphosphoguanine nucleotides with respect to enzyme activation. Concentration-dependence curves, analyzed by computer-aided curve fitting, revealed: (1) in the presence of 5 μM GTP there were two apparent affinities for parathyroid hormone (Km 9 and 98 nM) and isoproterenol (Km 72 and 340 nM); (2) and two affinites for guanosine-5′-(β,γ-imido)triphosphate (Km 0.25 and 1.3 μM); (3) hormones and guanine nucleotides reciprocally shifted each other's concentration dependence curves to the high affinity sites; (4) parathyroid hormone and isoproterenol interacting with high affinity sites competed for the same adenylate cyclase; (5) parathyroid hormone and isoproterenol, acting on low affinity sites had additive effects and also stimulated adenylate cyclase in the absence of added guanine nucleotides. The findings are consistent with: (i) competition of parathyroid hormone and isoproterenol for the activation of the high (hormone) affinity complex containing: receptors, nucleotide subunit, triphosphoguanine nucleotide, catalytic unit and (ii) the apparent presence of receptor-nucleotide sub-unit-GDP-catalytic unit complexes with low hormone affinity which are stimulated by parathyroid hormone and isoproterenol separately." @default.
• W2078447546 created "2016-06-24" @default.
• W2078447546 creator A5042186052 @default.
• W2078447546 creator A5058476835 @default.
• W2078447546 date "1981-01-01" @default.
• W2078447546 modified "2023-09-27" @default.
• W2078447546 title "Parathyroid hormone and isoproterenol stimulation of adenylate cyclase in rat osteosarcoma clonal cells Hormone competition and site heterogeneity" @default.
• W2078447546 cites W102993585 @default.
• W2078447546 cites W13135050 @default.
• W2078447546 cites W1480277012 @default.
• W2078447546 cites W1487187369 @default.
• W2078447546 cites W153702717 @default.
• W2078447546 cites W1578024134 @default.
• W2078447546 cites W1578156230 @default.
• W2078447546 cites W1581434205 @default.
• W2078447546 cites W1582088306 @default.
• W2078447546 cites W1596671341 @default.
• W2078447546 cites W182982796 @default.
• W2078447546 cites W1968785938 @default.
• W2078447546 cites W1969530315 @default.
• W2078447546 cites W1970150252 @default.
• W2078447546 cites W1979268262 @default.
• W2078447546 cites W1988394273 @default.
• W2078447546 cites W1996966147 @default.
• W2078447546 cites W2007270922 @default.
• W2078447546 cites W2045340281 @default.
• W2078447546 cites W2046517642 @default.
• W2078447546 cites W2075676530 @default.
• W2078447546 cites W2082831896 @default.
• W2078447546 cites W2083424491 @default.
• W2078447546 cites W2086603040 @default.
• W2078447546 cites W2120668704 @default.
• W2078447546 cites W2147483444 @default.
• W2078447546 cites W2152710595 @default.
• W2078447546 cites W2163168540 @default.
• W2078447546 cites W2169503005 @default.
• W2078447546 cites W2338240080 @default.
• W2078447546 cites W2400685989 @default.
• W2078447546 cites W2437607032 @default.
• W2078447546 cites W4252279173 @default.
• W2078447546 doi "https://doi.org/10.1016/0304-4165(81)90309-3" @default.
• W2078447546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6258654" @default.
• W2078447546 hasPublicationYear "1981" @default.
• W2078447546 type Work @default.
• W2078447546 sameAs 2078447546 @default.
• W2078447546 citedByCount "9" @default.
• W2078447546 countsByYear W20784475462022 @default.
• W2078447546 crossrefType "journal-article" @default.
• W2078447546 hasAuthorship W2078447546A5042186052 @default.
• W2078447546 hasAuthorship W2078447546A5058476835 @default.
• W2078447546 hasConcept C104317684 @default.
• W2078447546 hasConcept C118716 @default.
• W2078447546 hasConcept C121608353 @default.
• W2078447546 hasConcept C126322002 @default.
• W2078447546 hasConcept C134018914 @default.
• W2078447546 hasConcept C170493617 @default.
• W2078447546 hasConcept C178790620 @default.
• W2078447546 hasConcept C180526460 @default.
• W2078447546 hasConcept C181199279 @default.
• W2078447546 hasConcept C185592680 @default.
• W2078447546 hasConcept C23589133 @default.
• W2078447546 hasConcept C2776638253 @default.
• W2078447546 hasConcept C2777995097 @default.
• W2078447546 hasConcept C2778301229 @default.
• W2078447546 hasConcept C2779817904 @default.
• W2078447546 hasConcept C2780069284 @default.
• W2078447546 hasConcept C2781208988 @default.
• W2078447546 hasConcept C512185932 @default.
• W2078447546 hasConcept C519063684 @default.
• W2078447546 hasConcept C530470458 @default.
• W2078447546 hasConcept C54143909 @default.
• W2078447546 hasConcept C55493867 @default.
• W2078447546 hasConcept C71315377 @default.
• W2078447546 hasConcept C71924100 @default.
• W2078447546 hasConcept C86803240 @default.
• W2078447546 hasConceptScore W2078447546C104317684 @default.
• W2078447546 hasConceptScore W2078447546C118716 @default.
• W2078447546 hasConceptScore W2078447546C121608353 @default.
• W2078447546 hasConceptScore W2078447546C126322002 @default.
• W2078447546 hasConceptScore W2078447546C134018914 @default.
• W2078447546 hasConceptScore W2078447546C170493617 @default.
• W2078447546 hasConceptScore W2078447546C178790620 @default.
• W2078447546 hasConceptScore W2078447546C180526460 @default.
• W2078447546 hasConceptScore W2078447546C181199279 @default.
• W2078447546 hasConceptScore W2078447546C185592680 @default.
• W2078447546 hasConceptScore W2078447546C23589133 @default.
• W2078447546 hasConceptScore W2078447546C2776638253 @default.
• W2078447546 hasConceptScore W2078447546C2777995097 @default.
• W2078447546 hasConceptScore W2078447546C2778301229 @default.
• W2078447546 hasConceptScore W2078447546C2779817904 @default.
• W2078447546 hasConceptScore W2078447546C2780069284 @default.
• W2078447546 hasConceptScore W2078447546C2781208988 @default.
• W2078447546 hasConceptScore W2078447546C512185932 @default.
• W2078447546 hasConceptScore W2078447546C519063684 @default.
• W2078447546 hasConceptScore W2078447546C530470458 @default.
• W2078447546 hasConceptScore W2078447546C54143909 @default.
• W2078447546 hasConceptScore W2078447546C55493867 @default.
• W2078447546 hasConceptScore W2078447546C71315377 @default.

• next