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- W2078448009 abstract "Abstract Several strain-specific markers were found to be histochemically visualizable in parts of the central nervous system in allophenic mice. These markers therefore provide a new basis for mapping the normal developmental lineages of major parts of the nervous system, and for identifying the focus of mutant gene action in some neurological mutations. Cell strains in mosaic animals were visualized on the basis of a quantitative difference in β-galactosidase activity (Bgs-locus), in the Purkinje zone of the cerebellum, and in the hippocampal pyramidal zone of the cerebrum. The differential between strains was increased if the beige ( bg J bg J ) mutation was included in the high-activity strain. (β-galactosidase is lysosomal, and enhanced visualization in beige results from its enlarged and aggregated lysosomes.) Purkinje cell-strain visualization was also obtained by an indirect fluorescent antibody technique, in sections treated with antisera containing antibodies against strain-type histocompatibility alloantigens, including H-2. The above markers reveal considerable interspersion of cells from separate lineages in short sequences of each genotype. Purkinje and pyramidal cells of the same brain sometimes differ appreciably in genotypic composition. The enzyme glucosephosphate isomerase was found histochemically to be localized in nerve fibers rather than cell bodies in the brain. However, it was prominent in the cell bodies of the spinal ganglia, so that biochemical determination of ganglion strain-types is possible by means of strain-specific isozymes (Gpi-1-locus). Individual ganglia contained both cell strains and thus are not individually derived as clones from the neural crest." @default.
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- W2078448009 date "1976-05-01" @default.
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- W2078448009 title "Brain and ganglion development from two genotypic classes of cells in allophenic mice" @default.
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- W2078448009 doi "https://doi.org/10.1016/0012-1606(76)90068-3" @default.
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