FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078450592> ?p ?o ?g. }

• W2078450592 endingPage "204" @default.
• W2078450592 startingPage "187" @default.
• W2078450592 abstract "1. The role of serotonin (5-HT) and excitatory amino-acids (EAAs) in the activation of the neural networks (i.e. the central pattern generators) that organize locomotion in mammals was investigated in an isolated brainstem-spinal cord preparation from the newborn rat. 2. The neuroactive substances were bath applied and the activity of fictive locomotion was recorded in the ventral roots. 3. Serotonin initiated an alternating pattern of right and left action potential bursts. The period of this rhythm was dose dependent, i.e. it decreased from around 10 s at 2 x 10(-5) M to 5 s at 10(-4) M. The effects of serotonin were blocked by a 5-HT1 antagonist (propranolol) and by 5-HT2 antagonists (ketanserin, cyproheptadine, mianserin). 5-HT3 antagonists were ineffective. The effects of methoxytryptamine, a non-selective 5-HT agonist, mimicked the 5-HT effects. 4. The endogenous EAAs, glutamate and aspartate, also triggered an alternating rhythmic pattern. Their effects were blocked by 2-amino-5-phosphonovaleric acid (AP-5; a N-methyl-D-aspartate (NMDA) receptor blocker) and 6,7-dinitro-quinoxaline-2,3-dione (a non-NMDA receptor blocker). 5. Several EAA agonists (N-methyl-D,L-aspartate (NMA) and kainate) initiated rhythmic activity. The period of the induced rhythm (from 3 to 1 s) was similar with both of these substances but in a range of concentrations which was ten times lower in the case of kainate (10(-6) to 5 x 10(-6) M) than in that of NMA (10(-5) to 4 x 10(-5) M). alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionate and quisqualate occasionally triggered some episodes of fictive locomotion with a threshold at 6 x 10(-7) and 10(-5) M, respectively." @default.
• W2078450592 created "2016-06-24" @default.
• W2078450592 creator A5005642581 @default.
• W2078450592 creator A5030284375 @default.
• W2078450592 creator A5082482390 @default.
• W2078450592 date "1992-09-01" @default.
• W2078450592 modified "2023-10-06" @default.
• W2078450592 title "Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat." @default.
• W2078450592 cites W1507505324 @default.
• W2078450592 cites W1577210222 @default.
• W2078450592 cites W1937089820 @default.
• W2078450592 cites W1970596026 @default.
• W2078450592 cites W1971288017 @default.
• W2078450592 cites W1973002494 @default.
• W2078450592 cites W1975589228 @default.
• W2078450592 cites W1982508615 @default.
• W2078450592 cites W1990904400 @default.
• W2078450592 cites W1993090680 @default.
• W2078450592 cites W2000594498 @default.
• W2078450592 cites W2005072972 @default.
• W2078450592 cites W2021089817 @default.
• W2078450592 cites W2022238081 @default.
• W2078450592 cites W2032080035 @default.
• W2078450592 cites W2032454586 @default.
• W2078450592 cites W2037950501 @default.
• W2078450592 cites W2040238475 @default.
• W2078450592 cites W2047414779 @default.
• W2078450592 cites W2053375881 @default.
• W2078450592 cites W2054715468 @default.
• W2078450592 cites W2057537207 @default.
• W2078450592 cites W2057701938 @default.
• W2078450592 cites W2060910640 @default.
• W2078450592 cites W2062669886 @default.
• W2078450592 cites W2064996151 @default.
• W2078450592 cites W2086819817 @default.
• W2078450592 cites W2088047679 @default.
• W2078450592 cites W2090169119 @default.
• W2078450592 cites W2095056643 @default.
• W2078450592 cites W2114111541 @default.
• W2078450592 cites W2118284731 @default.
• W2078450592 cites W2166544347 @default.
• W2078450592 cites W2323397761 @default.
• W2078450592 cites W2398670490 @default.
• W2078450592 cites W2441887585 @default.
• W2078450592 doi "https://doi.org/10.1113/jphysiol.1992.sp019296" @default.
• W2078450592 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1175639" @default.
• W2078450592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1362441" @default.
• W2078450592 hasPublicationYear "1992" @default.
• W2078450592 type Work @default.
• W2078450592 sameAs 2078450592 @default.
• W2078450592 citedByCount "439" @default.
• W2078450592 countsByYear W20784505922012 @default.
• W2078450592 countsByYear W20784505922013 @default.
• W2078450592 countsByYear W20784505922014 @default.
• W2078450592 countsByYear W20784505922015 @default.
• W2078450592 countsByYear W20784505922016 @default.
• W2078450592 countsByYear W20784505922017 @default.
• W2078450592 countsByYear W20784505922018 @default.
• W2078450592 countsByYear W20784505922019 @default.
• W2078450592 countsByYear W20784505922020 @default.
• W2078450592 countsByYear W20784505922021 @default.
• W2078450592 countsByYear W20784505922022 @default.
• W2078450592 countsByYear W20784505922023 @default.
• W2078450592 crossrefType "journal-article" @default.
• W2078450592 hasAuthorship W2078450592A5005642581 @default.
• W2078450592 hasAuthorship W2078450592A5030284375 @default.
• W2078450592 hasAuthorship W2078450592A5082482390 @default.
• W2078450592 hasBestOaLocation W20784505922 @default.
• W2078450592 hasConcept C126322002 @default.
• W2078450592 hasConcept C134018914 @default.
• W2078450592 hasConcept C160268369 @default.
• W2078450592 hasConcept C170493617 @default.
• W2078450592 hasConcept C185592680 @default.
• W2078450592 hasConcept C189184402 @default.
• W2078450592 hasConcept C200220013 @default.
• W2078450592 hasConcept C2775864247 @default.
• W2078450592 hasConcept C2777448245 @default.
• W2078450592 hasConcept C2777785214 @default.
• W2078450592 hasConcept C2778938600 @default.
• W2078450592 hasConcept C2779803574 @default.
• W2078450592 hasConcept C2780076171 @default.
• W2078450592 hasConcept C2780831388 @default.
• W2078450592 hasConcept C53910766 @default.
• W2078450592 hasConcept C61174792 @default.
• W2078450592 hasConcept C67018056 @default.
• W2078450592 hasConcept C71924100 @default.
• W2078450592 hasConcept C86803240 @default.
• W2078450592 hasConcept C98274493 @default.
• W2078450592 hasConceptScore W2078450592C126322002 @default.
• W2078450592 hasConceptScore W2078450592C134018914 @default.
• W2078450592 hasConceptScore W2078450592C160268369 @default.
• W2078450592 hasConceptScore W2078450592C170493617 @default.
• W2078450592 hasConceptScore W2078450592C185592680 @default.
• W2078450592 hasConceptScore W2078450592C189184402 @default.
• W2078450592 hasConceptScore W2078450592C200220013 @default.
• W2078450592 hasConceptScore W2078450592C2775864247 @default.
• W2078450592 hasConceptScore W2078450592C2777448245 @default.
• W2078450592 hasConceptScore W2078450592C2777785214 @default.

• next