FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078454897> ?p ?o ?g. }

• W2078454897 endingPage "270" @default.
• W2078454897 startingPage "265" @default.
• W2078454897 abstract "Abstract. presented to the European Association for the Study of Diabetes, September 1990 and the 6th International Congress on Obesity, October 1990 Abstract. Obesity is a multifactorial disease with a marked genetic component. The situation is further complicated by the heterogeneity of obesity demonstrated by the topographical distribution of body fat, e.g. upper body (central) and lower body (gluteal) obesity. Furthermore, the distribution of fat shows a stronger heritable tendency compared with total body fat. Central obesity is characterized by hyperinsulinaemia and insulin resistance, a feature in common with non-insulin dependent diabetes mellitus, hypertension and atherosclerosis. In order to study the molecular genetics of central obesity we have examined 56 severely obese (mean body mass index 40), unrelated British Caucasoid young non-diabetic women for associations of restriction fragment length polymorphism of candidate genes with anthropometric measurements and indices of insulin secretion and resistance. The candidate genes examined were insulin receptor, insulin sensitive glucose transporter and insulin. An association of the class 3 allele of the hypervari-able region in the 5′ flanking region of the insulin gene was found with upper segment obesity (P=0.005). Furthermore, the class 3 allele was also associated with fasting hyperinsulinaemia (P=0.01), stimulated insulin secretion (P= 0.01) and insulin resistance as calculated from the homeostatic model of assessment (HOMA; P= 0.008). No such associations were found with the other candidate genes studied. This data suggests that polymorphisms in the 5′ flanking region of the insulin gene may affect expression of the gene and thereby modulate insulin production in severely obese female subjects." @default.
• W2078454897 created "2016-06-24" @default.
• W2078454897 creator A5014747220 @default.
• W2078454897 creator A5021268110 @default.
• W2078454897 creator A5050134647 @default.
• W2078454897 date "1992-04-01" @default.
• W2078454897 modified "2023-09-25" @default.
• W2078454897 title "Central obesity and hyperinsulinaemia in women are associated with polymorphism in the 5‘ flanking region of the human insulin gene" @default.
• W2078454897 cites W1506727751 @default.
• W2078454897 cites W1978401057 @default.
• W2078454897 cites W1982695586 @default.
• W2078454897 cites W1983955079 @default.
• W2078454897 cites W1988319483 @default.
• W2078454897 cites W1990948459 @default.
• W2078454897 cites W1991710558 @default.
• W2078454897 cites W1991902010 @default.
• W2078454897 cites W1993164455 @default.
• W2078454897 cites W2002702884 @default.
• W2078454897 cites W2006489473 @default.
• W2078454897 cites W2011180318 @default.
• W2078454897 cites W2014520847 @default.
• W2078454897 cites W2022343395 @default.
• W2078454897 cites W2028749920 @default.
• W2078454897 cites W2054694895 @default.
• W2078454897 cites W2058831382 @default.
• W2078454897 cites W2066338261 @default.
• W2078454897 cites W2066935824 @default.
• W2078454897 cites W2091008564 @default.
• W2078454897 cites W2094945603 @default.
• W2078454897 cites W2095173006 @default.
• W2078454897 cites W2160234571 @default.
• W2078454897 cites W2319231450 @default.
• W2078454897 cites W2326432204 @default.
• W2078454897 cites W2335145280 @default.
• W2078454897 cites W2464014995 @default.
• W2078454897 cites W4229940421 @default.
• W2078454897 cites W4234830920 @default.
• W2078454897 cites W4235880198 @default.
• W2078454897 cites W4236293504 @default.
• W2078454897 cites W4237742792 @default.
• W2078454897 doi "https://doi.org/10.1111/j.1365-2362.1992.tb01461.x" @default.
• W2078454897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1354160" @default.
• W2078454897 hasPublicationYear "1992" @default.
• W2078454897 type Work @default.
• W2078454897 sameAs 2078454897 @default.
• W2078454897 citedByCount "77" @default.
• W2078454897 countsByYear W20784548972012 @default.
• W2078454897 countsByYear W20784548972013 @default.
• W2078454897 crossrefType "journal-article" @default.
• W2078454897 hasAuthorship W2078454897A5014747220 @default.
• W2078454897 hasAuthorship W2078454897A5021268110 @default.
• W2078454897 hasAuthorship W2078454897A5050134647 @default.
• W2078454897 hasConcept C104317684 @default.
• W2078454897 hasConcept C112446052 @default.
• W2078454897 hasConcept C126322002 @default.
• W2078454897 hasConcept C134018914 @default.
• W2078454897 hasConcept C180754005 @default.
• W2078454897 hasConcept C2777391703 @default.
• W2078454897 hasConcept C2779306644 @default.
• W2078454897 hasConcept C2780221984 @default.
• W2078454897 hasConcept C2780988686 @default.
• W2078454897 hasConcept C3018667095 @default.
• W2078454897 hasConcept C511355011 @default.
• W2078454897 hasConcept C54355233 @default.
• W2078454897 hasConcept C555293320 @default.
• W2078454897 hasConcept C69991583 @default.
• W2078454897 hasConcept C71924100 @default.
• W2078454897 hasConcept C86803240 @default.
• W2078454897 hasConceptScore W2078454897C104317684 @default.
• W2078454897 hasConceptScore W2078454897C112446052 @default.
• W2078454897 hasConceptScore W2078454897C126322002 @default.
• W2078454897 hasConceptScore W2078454897C134018914 @default.
• W2078454897 hasConceptScore W2078454897C180754005 @default.
• W2078454897 hasConceptScore W2078454897C2777391703 @default.
• W2078454897 hasConceptScore W2078454897C2779306644 @default.
• W2078454897 hasConceptScore W2078454897C2780221984 @default.
• W2078454897 hasConceptScore W2078454897C2780988686 @default.
• W2078454897 hasConceptScore W2078454897C3018667095 @default.
• W2078454897 hasConceptScore W2078454897C511355011 @default.
• W2078454897 hasConceptScore W2078454897C54355233 @default.
• W2078454897 hasConceptScore W2078454897C555293320 @default.
• W2078454897 hasConceptScore W2078454897C69991583 @default.
• W2078454897 hasConceptScore W2078454897C71924100 @default.
• W2078454897 hasConceptScore W2078454897C86803240 @default.
• W2078454897 hasIssue "4" @default.
• W2078454897 hasLocation W20784548971 @default.
• W2078454897 hasLocation W20784548972 @default.
• W2078454897 hasOpenAccess W2078454897 @default.
• W2078454897 hasPrimaryLocation W20784548971 @default.
• W2078454897 hasRelatedWork W2010140898 @default.
• W2078454897 hasRelatedWork W2058152093 @default.
• W2078454897 hasRelatedWork W2082140668 @default.
• W2078454897 hasRelatedWork W2138266804 @default.
• W2078454897 hasRelatedWork W2166224820 @default.
• W2078454897 hasRelatedWork W2416996015 @default.
• W2078454897 hasRelatedWork W2886303208 @default.
• W2078454897 hasRelatedWork W3034699979 @default.
• W2078454897 hasRelatedWork W4230217464 @default.

• next