FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078454905> ?p ?o ?g. }

• W2078454905 endingPage "106" @default.
• W2078454905 startingPage "98" @default.
• W2078454905 abstract "Nonsteroidal anti-inflammatory drugs (NSAIDs) are mainstays of the treatment of osteoarthritis (OA) but have dose- and age-related risks of gastrointestinal, cardiovascular, and renal adverse events (AEs). As a result, US and international guidelines recommend caution when prescribing oral NSAIDs, particularly in older patients and those with significant comorbidities. For OA of the hands and knees, topical NSAIDs provide efficacy similar to oral NSAIDs, with far less systemic distribution. Treatment-related cardiovascular, renal, and other serious AEs with topical NSAIDs have not been reported. At present, only 2 topical NSAIDs are approved in the United States for the treatment of OA: diclofenac sodium 1% gel for hand or knee OA and diclofenac sodium 1.5% in 45.5% dimethylsulfoxide solution for knee OA. Clinical trial data for these products have demonstrated efficacy superior to placebo or similar to oral diclofenac with AE profiles similar to placebo, except for application site reactions. In large double-blind trials, gastrointestinal AEs were infrequent and did not include ulcers, perforations, or bleeding. The purpose of this brief review is to examine the data from controlled double-blind trials evaluating the use of topical NSAIDs in patients with OA. Articles included were identified via a search of PubMed covering the period from January 1, 2005 through March 31, 2010. Reference lists from OA treatment guidelines and meta-analyses were reviewed for additional citations of importance." @default.
• W2078454905 created "2016-06-24" @default.
• W2078454905 creator A5026346646 @default.
• W2078454905 creator A5061623656 @default.
• W2078454905 date "2010-11-01" @default.
• W2078454905 modified "2023-09-26" @default.
• W2078454905 title "Topical Nonsteroidal Anti-Inflammatory Drugs for Osteoarthritis" @default.
• W2078454905 cites W1480874656 @default.
• W2078454905 cites W1494229485 @default.
• W2078454905 cites W1504194645 @default.
• W2078454905 cites W1890512155 @default.
• W2078454905 cites W1965869386 @default.
• W2078454905 cites W1969798546 @default.
• W2078454905 cites W1977061321 @default.
• W2078454905 cites W1978759500 @default.
• W2078454905 cites W1982515380 @default.
• W2078454905 cites W2010860405 @default.
• W2078454905 cites W2023377426 @default.
• W2078454905 cites W2032731780 @default.
• W2078454905 cites W2038932922 @default.
• W2078454905 cites W2051826678 @default.
• W2078454905 cites W2052744840 @default.
• W2078454905 cites W2055336840 @default.
• W2078454905 cites W2057878174 @default.
• W2078454905 cites W2073917243 @default.
• W2078454905 cites W2076748018 @default.
• W2078454905 cites W2084289720 @default.
• W2078454905 cites W2102043593 @default.
• W2078454905 cites W2102855933 @default.
• W2078454905 cites W2109399977 @default.
• W2078454905 cites W2113079259 @default.
• W2078454905 cites W2113737049 @default.
• W2078454905 cites W2116143759 @default.
• W2078454905 cites W2120551915 @default.
• W2078454905 cites W2124433729 @default.
• W2078454905 cites W2125205359 @default.
• W2078454905 cites W2129208878 @default.
• W2078454905 cites W2139124406 @default.
• W2078454905 cites W2146447031 @default.
• W2078454905 cites W2261853236 @default.
• W2078454905 cites W4244537139 @default.
• W2078454905 cites W4248592944 @default.
• W2078454905 cites W4250528986 @default.
• W2078454905 cites W4367329927 @default.
• W2078454905 cites W4376595560 @default.
• W2078454905 doi "https://doi.org/10.3810/pgm.2010.11.2227" @default.
• W2078454905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21084786" @default.
• W2078454905 hasPublicationYear "2010" @default.
• W2078454905 type Work @default.
• W2078454905 sameAs 2078454905 @default.
• W2078454905 citedByCount "29" @default.
• W2078454905 countsByYear W20784549052012 @default.
• W2078454905 countsByYear W20784549052013 @default.
• W2078454905 countsByYear W20784549052014 @default.
• W2078454905 countsByYear W20784549052015 @default.
• W2078454905 countsByYear W20784549052016 @default.
• W2078454905 countsByYear W20784549052017 @default.
• W2078454905 countsByYear W20784549052018 @default.
• W2078454905 countsByYear W20784549052019 @default.
• W2078454905 countsByYear W20784549052022 @default.
• W2078454905 crossrefType "journal-article" @default.
• W2078454905 hasAuthorship W2078454905A5026346646 @default.
• W2078454905 hasAuthorship W2078454905A5061623656 @default.
• W2078454905 hasConcept C126322002 @default.
• W2078454905 hasConcept C142724271 @default.
• W2078454905 hasConcept C197934379 @default.
• W2078454905 hasConcept C204787440 @default.
• W2078454905 hasConcept C27081682 @default.
• W2078454905 hasConcept C2776164576 @default.
• W2078454905 hasConcept C2776467144 @default.
• W2078454905 hasConcept C2778484676 @default.
• W2078454905 hasConcept C2779826273 @default.
• W2078454905 hasConcept C2908765736 @default.
• W2078454905 hasConcept C42219234 @default.
• W2078454905 hasConcept C535046627 @default.
• W2078454905 hasConcept C71924100 @default.
• W2078454905 hasConcept C98274493 @default.
• W2078454905 hasConceptScore W2078454905C126322002 @default.
• W2078454905 hasConceptScore W2078454905C142724271 @default.
• W2078454905 hasConceptScore W2078454905C197934379 @default.
• W2078454905 hasConceptScore W2078454905C204787440 @default.
• W2078454905 hasConceptScore W2078454905C27081682 @default.
• W2078454905 hasConceptScore W2078454905C2776164576 @default.
• W2078454905 hasConceptScore W2078454905C2776467144 @default.
• W2078454905 hasConceptScore W2078454905C2778484676 @default.
• W2078454905 hasConceptScore W2078454905C2779826273 @default.
• W2078454905 hasConceptScore W2078454905C2908765736 @default.
• W2078454905 hasConceptScore W2078454905C42219234 @default.
• W2078454905 hasConceptScore W2078454905C535046627 @default.
• W2078454905 hasConceptScore W2078454905C71924100 @default.
• W2078454905 hasConceptScore W2078454905C98274493 @default.
• W2078454905 hasIssue "6" @default.
• W2078454905 hasLocation W20784549051 @default.
• W2078454905 hasLocation W20784549052 @default.
• W2078454905 hasOpenAccess W2078454905 @default.
• W2078454905 hasPrimaryLocation W20784549051 @default.
• W2078454905 hasRelatedWork W1581863768 @default.
• W2078454905 hasRelatedWork W1990986050 @default.

• next