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- W2078455515 abstract "A series of monosubstituted benzenes, hydroxybenzenes, monosubstituted phenols, and hydroxynaphthalenes were screened for their ability to produce convulsions in mice. Phenol was the only monosubstituted benzene which possessed convulsant activity. Catechol was the most potent hydroxybenzene. Substitution of various chemical groups in the o-position in phenol was found to decrease (relative to catechol), or abolish the convulsant activity. The relative potencies of the hydroxybenzenes were determined from the CD50 values and from dose/convulsion response curves; close agreement between the 2 methods was found. Pyrogallol (1,2,3-trihydroxybenzene) did not produce convulsions, but on the contrary, produced somnolence when administered to normal animals and diminished the excitatory effect of d-amphetamine on locomotor activity. Monohydroxynaphthalenes or dihydroxynaphthalenes with both hydroxyl groups on the same ring, did not produce convulsions. Other dihydroxynaphthalenes (1,5-, 1,7-, 2,6-, and 2,7) were active and had potencies similar to or less than phenol." @default.
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- W2078455515 date "1972-02-01" @default.
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- W2078455515 title "An analysis of the convulsant activity of substituted benzenes in the mouse" @default.
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- W2078455515 doi "https://doi.org/10.1016/0041-008x(72)90064-6" @default.
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