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- W2078455840 abstract "A number of poly(ether-ester) azo polymers consisting of various concentrations of 4-{2-[2-(2-hydroxyethoxy) ethoxy]ethoxy} benzoic acid (HEEEBA), 4-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}phenylazobenzoic acid (HEEEPABA) and either 12-hydroxydodecanoic or 16-hydroxyhexadecanoic acid were synthesized. The polymers were assessed in order to determine whether they are biodegradable by the azoreductase present in the rat caecum. The polymers containing HEEEBA showed satisfactory degradation (up to 48%), while those without showed poor degradation, due to poor wettability. When 1% polysorbate 80 (a wetting agent) was added to the polymers in the degradation medium, all polymers showed excellent degradation. Azo polymers with HEEEBA have the potential to be used as colon-specific drug release materials." @default.
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- W2078455840 date "1995-07-01" @default.
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- W2078455840 title "Synthesis and in vitro biodegradation of poly(ether-ester) azo polymers designed for colon targeting" @default.
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- W2078455840 doi "https://doi.org/10.1016/0378-5173(95)00023-c" @default.
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