Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078458210> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2078458210 endingPage "4" @default.
- W2078458210 startingPage "1" @default.
- W2078458210 abstract "When DNA damage arises in a eukaryotic genome, the repair machinery acts on a substrate that is packaged into chromatin. Over the past decade, we have begun to appreciate the importance of this distinction. A series of reviews in this issue examines how the DNA double-strand break (DSB) repair sensing, signaling, and repair machinery accesses and exploits a chromatinized DNA substrate to orchestrate DSB repair. There are two fundamental questions that are addressed throughout these reviews. What physical constraints does chromatin structure place on DSB repair? How is chromatin used as a signaling platform in the DNA damage response? These questions are closely related because processes that control chromatin structure can also control signaling. For example, the acetylation of histone H4 on lysine 16 is both a switch between the 10 nm and 30 nm chromatin fiber structures[1] and an inhibitor of 53BP1 binding to chromatin surrounding the DSB [2, 3]. It is important to understand both chromatin structure and DSB signaling in order to understand the regulation of DSB repair. Collectively, the reviews in this issue bring us up to date on these important areas that define the interface between chromatin structure and DSB repair biochemistry." @default.
- W2078458210 created "2016-06-24" @default.
- W2078458210 creator A5073472372 @default.
- W2078458210 creator A5076392308 @default.
- W2078458210 date "2013-10-01" @default.
- W2078458210 modified "2023-09-27" @default.
- W2078458210 title "Conversations between chromatin modifications and DNA double strand break repair: A commentary" @default.
- W2078458210 cites W1968943627 @default.
- W2078458210 cites W1969503475 @default.
- W2078458210 cites W1972916418 @default.
- W2078458210 cites W1988259427 @default.
- W2078458210 cites W1999952815 @default.
- W2078458210 cites W2002137232 @default.
- W2078458210 cites W2002698073 @default.
- W2078458210 cites W2008185037 @default.
- W2078458210 cites W2008650297 @default.
- W2078458210 cites W2008787273 @default.
- W2078458210 cites W2019025864 @default.
- W2078458210 cites W2032348296 @default.
- W2078458210 cites W2033172828 @default.
- W2078458210 cites W2036477200 @default.
- W2078458210 cites W2037508254 @default.
- W2078458210 cites W2056236909 @default.
- W2078458210 cites W2060247906 @default.
- W2078458210 cites W2068973408 @default.
- W2078458210 cites W2069328568 @default.
- W2078458210 cites W2070021921 @default.
- W2078458210 cites W2070660722 @default.
- W2078458210 cites W2071787911 @default.
- W2078458210 cites W2099077495 @default.
- W2078458210 cites W2102604046 @default.
- W2078458210 cites W2106482095 @default.
- W2078458210 cites W2118629005 @default.
- W2078458210 cites W2120943086 @default.
- W2078458210 cites W2132396299 @default.
- W2078458210 cites W2142826475 @default.
- W2078458210 cites W2145869787 @default.
- W2078458210 cites W2145929363 @default.
- W2078458210 cites W2146729875 @default.
- W2078458210 cites W2156238710 @default.
- W2078458210 doi "https://doi.org/10.1016/j.mrfmmm.2013.08.003" @default.
- W2078458210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3827952" @default.
- W2078458210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23994712" @default.
- W2078458210 hasPublicationYear "2013" @default.
- W2078458210 type Work @default.
- W2078458210 sameAs 2078458210 @default.
- W2078458210 citedByCount "3" @default.
- W2078458210 countsByYear W20784582102014 @default.
- W2078458210 countsByYear W20784582102016 @default.
- W2078458210 countsByYear W20784582102018 @default.
- W2078458210 crossrefType "journal-article" @default.
- W2078458210 hasAuthorship W2078458210A5073472372 @default.
- W2078458210 hasAuthorship W2078458210A5076392308 @default.
- W2078458210 hasBestOaLocation W20784582102 @default.
- W2078458210 hasConcept C54355233 @default.
- W2078458210 hasConcept C552990157 @default.
- W2078458210 hasConcept C70721500 @default.
- W2078458210 hasConcept C83640560 @default.
- W2078458210 hasConcept C86803240 @default.
- W2078458210 hasConceptScore W2078458210C54355233 @default.
- W2078458210 hasConceptScore W2078458210C552990157 @default.
- W2078458210 hasConceptScore W2078458210C70721500 @default.
- W2078458210 hasConceptScore W2078458210C83640560 @default.
- W2078458210 hasConceptScore W2078458210C86803240 @default.
- W2078458210 hasIssue "1-2" @default.
- W2078458210 hasLocation W20784582101 @default.
- W2078458210 hasLocation W20784582102 @default.
- W2078458210 hasLocation W20784582103 @default.
- W2078458210 hasLocation W20784582104 @default.
- W2078458210 hasOpenAccess W2078458210 @default.
- W2078458210 hasPrimaryLocation W20784582101 @default.
- W2078458210 hasRelatedWork W1828691184 @default.
- W2078458210 hasRelatedWork W1991523530 @default.
- W2078458210 hasRelatedWork W2002128513 @default.
- W2078458210 hasRelatedWork W2013095276 @default.
- W2078458210 hasRelatedWork W2036519228 @default.
- W2078458210 hasRelatedWork W2045160500 @default.
- W2078458210 hasRelatedWork W3004515236 @default.
- W2078458210 hasRelatedWork W3004761543 @default.
- W2078458210 hasRelatedWork W4255802083 @default.
- W2078458210 hasRelatedWork W2092874662 @default.
- W2078458210 hasVolume "750" @default.
- W2078458210 isParatext "false" @default.
- W2078458210 isRetracted "false" @default.
- W2078458210 magId "2078458210" @default.
- W2078458210 workType "article" @default.