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- W2078459232 abstract "Several case-control and prospective studies have reported that increased white blood cell (WBC) count is an independent risk factor for coronary heart disease, cardiovascular events, and mortality. 1 Friedman G.D Klatsky A.L Sieglaub A.B The leukocyte count as a predictor of myocardial infarction. N Engl J Med. 1974; 290: 1275-1278 Crossref PubMed Scopus (405) Google Scholar , 2 Phillips A Neaton J.D Look D.G Grimm R.H Shaper A.G Leukocyte count and risk of major coronary heart disease events. Am J Epidemiol. 1992; 136: 59-70 Crossref PubMed Scopus (92) Google Scholar , 3 Gillum R.F Ingram D.D Makuc D.M White blood cell count, coronary heart disease and death the NHANES I Epidemiologic Follow-up Study. Am Heart J. 1993; 125: 855-868 Abstract Full Text PDF PubMed Scopus (112) Google Scholar , 4 Danesh J Collins R Appleby P Peto R Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease. Meta-analyses of prospective studies. JAMA. 1998; 279: 1477-1488 Crossref PubMed Scopus (1819) Google Scholar An elevated WBC count has been associated with both a higher risk of developing myocardial infarction and worse outcome in post–myocardial infarction patients. 5 Zalokar J.B Richard J.L Claude J.R Leukocyte count, smoking and myocardial infarction. N Engl J Med. 1981; 304: 465-468 Crossref PubMed Scopus (224) Google Scholar , 6 Burr M.I Holliday R.M Fehily A.M Whitehead P.J Haematological prognostic indices after myocardial infarction evidence from the diet and reinfarction trial (DART). Eur Heart J. 1992; 13: 166-170 Crossref PubMed Scopus (100) Google Scholar , 7 Furman M.I Becker R.C Yarzebski J Savegeau J Gore J.M Goldberg R.J Effect of elevated leukocyte count on in-hospital mortality following acute myocardial infarction. Am J Cardiol. 1996; 78: 945-948 Abstract Full Text Full Text PDF PubMed Scopus (103) Google Scholar It has been also reported that relative lymphocyte count may have prognostic significance in patients with known or suspected coronary heart disease. 8 Evans M.A Hodge D.O Smars P.A Thosom S.P Gibbon R.J The prognostic value of the leukocyte differential in the evaluation of patients presenting with chest pain (abstr). Circulation. 1995; 92: I664 Google Scholar , 9 Ommen S.R Gibbons R.J Hodge D.O Thomson S.P Usefulness of the lymphocyte concentration as a prognostic marker in coronary artery disease. Am J Cardiol. 1997; 79: 812-814 Abstract Full Text Full Text PDF PubMed Scopus (201) Google Scholar However, the relation between WBC count and prognosis in patients with unstable angina has not been investigated systematically. In acute coronary syndromes, markers of increased risk, such as cardiac troponin-I exist, which have been shown to be useful for patient risk stratification. 10 Christenson R.H Duh S.H Newby L.K Ohman E.M Califf R.M Granger C.B Peck S Pieper K.S Armstrong P.W Katus H.A Topol E.J Cardiac troponin T and cardiac troponin I relative values in short-term risk stratification of patients with acute coronary syndromes. GUSTO-IIa Investigators. Clin Chem. 1998; 44: 494-501 PubMed Google Scholar , 11 Galvani M Ottani F Ferrini D Ladenson J.H Destro A Baccos D Rusticali F Jaffe A.S Prognostic influence of elevated values of cardiac troponin I in patients with unstable angina. Circulation. 1997; 95: 2053-2059 Crossref PubMed Scopus (314) Google Scholar" @default.
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- W2078459232 title "Usefulness of the blood lymphocyte count in predicting recurrent instability and death in patients with unstable angina pectoris" @default.
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