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• W2078461037 abstract "Peptides presented at the cell surface reflect the protein content of the cell; those on HLA class I molecules comprise the critical peptidome elements interacting with CD8 T lymphocytes. We hypothesize that peptidomes from ex vivo tumour samples encompass immunogenic tumour antigens. Here, we uncover >6000 HLA-bound peptides from HLA-A*02+ glioblastoma, of which over 3000 were restricted by HLA-A*02. We prioritized in-depth investigation of 10 glioblastoma-associated antigens based on high expression in tumours, very low or absent expression in healthy tissues, implication in gliomagenesis and immunogenicity. Patients with glioblastoma showed no T cell tolerance to these peptides. Moreover, we demonstrated specific lysis of tumour cells by patients’ CD8+ T cells in vitro. In vivo, glioblastoma-specific CD8+ T cells were present at the tumour site. Overall, our data show the physiological relevance of the peptidome approach and provide a critical advance for designing a rational glioblastoma immunotherapy. The peptides identified in our study are currently being tested as a multipeptide vaccine (IMA950) in patients with glioblastoma." @default.
• W2078461037 created "2016-06-24" @default.
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• W2078461037 date "2012-02-14" @default.
• W2078461037 modified "2023-10-16" @default.
• W2078461037 title "Exploiting the glioblastoma peptidome to discover novel tumour-associated antigens for immunotherapy" @default.
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• W2078461037 doi "https://doi.org/10.1093/brain/aws042" @default.
• W2078461037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22418738" @default.
• W2078461037 hasPublicationYear "2012" @default.
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