Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078461915> ?p ?o ?g. }
- W2078461915 endingPage "433" @default.
- W2078461915 startingPage "426" @default.
- W2078461915 abstract "Abstract The Ketogenic diet ( KD ) is an effective treatment with regards to treating pharmaco‐resistant epilepsy. However, there are difficulties around compliance and tolerability. Consequently, there is a need for refined/simpler formulations that could replicate the efficacy of the KD . One of the proposed hypotheses is that the KD increases cellular mitochondrial content which results in elevation of the seizure threshold. Here, we have focussed on the medium‐chain triglyceride form of the diet and the observation that plasma octanoic acid (C8) and decanoic acid (C10) levels are elevated in patients on the medium‐chain triglyceride KD . Using a neuronal cell line ( SH ‐ SY 5Y), we demonstrated that 250‐μM C10, but not C8, caused, over a 6‐day period, a marked increase in the mitochondrial enzyme, citrate synthase along with complex I activity and catalase activity. Increased mitochondrial number was also indicated by electron microscopy. C10 is a reported peroxisome proliferator activator receptor γ agonist, and the use of a peroxisome proliferator activator receptor γ antagonist was shown to prevent the C10‐mediated increase in mitochondrial content and catalase. C10 may mimic the mitochondrial proliferation associated with the KD and raises the possibility that formulations based on this fatty acid could replace a more complex diet. image We propose that decanoic acid (C10) results in increased mitochondrial number. Our data suggest that this may occur via the activation of the PPARγ receptor and its target genes involved in mitochondrial biogenesis. This finding could be of significant benefit to epilepsy patients who are currently on a strict ketogenic diet. Evidence that C10 on its own can modulate mitochondrial number raises the possibility that a simplified and less stringent C10‐based diet could be developed." @default.
- W2078461915 created "2016-06-24" @default.
- W2078461915 creator A5000013257 @default.
- W2078461915 creator A5030885858 @default.
- W2078461915 creator A5038220789 @default.
- W2078461915 creator A5039068101 @default.
- W2078461915 creator A5045733414 @default.
- W2078461915 creator A5051710796 @default.
- W2078461915 creator A5058744331 @default.
- W2078461915 creator A5071083583 @default.
- W2078461915 creator A5084491163 @default.
- W2078461915 creator A5084991073 @default.
- W2078461915 date "2014-01-25" @default.
- W2078461915 modified "2023-10-17" @default.
- W2078461915 title "The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells" @default.
- W2078461915 cites W1586703136 @default.
- W2078461915 cites W1768247331 @default.
- W2078461915 cites W1804279373 @default.
- W2078461915 cites W1851045557 @default.
- W2078461915 cites W1970474244 @default.
- W2078461915 cites W1973927489 @default.
- W2078461915 cites W1990800885 @default.
- W2078461915 cites W2003763099 @default.
- W2078461915 cites W2013548876 @default.
- W2078461915 cites W2014713991 @default.
- W2078461915 cites W2024671481 @default.
- W2078461915 cites W2026311526 @default.
- W2078461915 cites W2028278441 @default.
- W2078461915 cites W2037047111 @default.
- W2078461915 cites W2038531680 @default.
- W2078461915 cites W2038693299 @default.
- W2078461915 cites W2043595793 @default.
- W2078461915 cites W2045851185 @default.
- W2078461915 cites W2051579224 @default.
- W2078461915 cites W2055308573 @default.
- W2078461915 cites W2060896332 @default.
- W2078461915 cites W2062452059 @default.
- W2078461915 cites W2070442887 @default.
- W2078461915 cites W2072349303 @default.
- W2078461915 cites W2079762064 @default.
- W2078461915 cites W2102131116 @default.
- W2078461915 cites W2104841128 @default.
- W2078461915 cites W2112744358 @default.
- W2078461915 cites W2120924125 @default.
- W2078461915 cites W2127978123 @default.
- W2078461915 cites W2143172845 @default.
- W2078461915 cites W2159036789 @default.
- W2078461915 cites W2161771594 @default.
- W2078461915 cites W962061814 @default.
- W2078461915 doi "https://doi.org/10.1111/jnc.12646" @default.
- W2078461915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24383952" @default.
- W2078461915 hasPublicationYear "2014" @default.
- W2078461915 type Work @default.
- W2078461915 sameAs 2078461915 @default.
- W2078461915 citedByCount "146" @default.
- W2078461915 countsByYear W20784619152014 @default.
- W2078461915 countsByYear W20784619152015 @default.
- W2078461915 countsByYear W20784619152016 @default.
- W2078461915 countsByYear W20784619152017 @default.
- W2078461915 countsByYear W20784619152018 @default.
- W2078461915 countsByYear W20784619152019 @default.
- W2078461915 countsByYear W20784619152020 @default.
- W2078461915 countsByYear W20784619152021 @default.
- W2078461915 countsByYear W20784619152022 @default.
- W2078461915 countsByYear W20784619152023 @default.
- W2078461915 crossrefType "journal-article" @default.
- W2078461915 hasAuthorship W2078461915A5000013257 @default.
- W2078461915 hasAuthorship W2078461915A5030885858 @default.
- W2078461915 hasAuthorship W2078461915A5038220789 @default.
- W2078461915 hasAuthorship W2078461915A5039068101 @default.
- W2078461915 hasAuthorship W2078461915A5045733414 @default.
- W2078461915 hasAuthorship W2078461915A5051710796 @default.
- W2078461915 hasAuthorship W2078461915A5058744331 @default.
- W2078461915 hasAuthorship W2078461915A5071083583 @default.
- W2078461915 hasAuthorship W2078461915A5084491163 @default.
- W2078461915 hasAuthorship W2078461915A5084991073 @default.
- W2078461915 hasBestOaLocation W20784619151 @default.
- W2078461915 hasConcept C111133373 @default.
- W2078461915 hasConcept C126322002 @default.
- W2078461915 hasConcept C127078168 @default.
- W2078461915 hasConcept C134018914 @default.
- W2078461915 hasConcept C170493617 @default.
- W2078461915 hasConcept C181199279 @default.
- W2078461915 hasConcept C2776950135 @default.
- W2078461915 hasConcept C2777229759 @default.
- W2078461915 hasConcept C28859421 @default.
- W2078461915 hasConcept C55493867 @default.
- W2078461915 hasConcept C71924100 @default.
- W2078461915 hasConcept C86803240 @default.
- W2078461915 hasConceptScore W2078461915C111133373 @default.
- W2078461915 hasConceptScore W2078461915C126322002 @default.
- W2078461915 hasConceptScore W2078461915C127078168 @default.
- W2078461915 hasConceptScore W2078461915C134018914 @default.
- W2078461915 hasConceptScore W2078461915C170493617 @default.
- W2078461915 hasConceptScore W2078461915C181199279 @default.
- W2078461915 hasConceptScore W2078461915C2776950135 @default.
- W2078461915 hasConceptScore W2078461915C2777229759 @default.
- W2078461915 hasConceptScore W2078461915C28859421 @default.