FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078462004> ?p ?o ?g. }

• W2078462004 endingPage "1640" @default.
• W2078462004 startingPage "1633" @default.
• W2078462004 abstract "The protozoan Trypanosoma cruzi, the causative agent of Chagas’ disease, can infect the heart, causing cardiac arrest frequently followed by death. To treat this disease, a potential molecular drug target is T. cruzi trans-sialidase (TcTS). However, inhibitors found to date are not strong enough to serve as a lead scaffold; most inhibitors reported thus far are derivatives of the substrate sialic acid or a transition state analogue known as 2,3-dehydro-3-deoxy-N-acetylneuraminic acid (DANA) with an IC50 value of more than hundreds of micromolar. Since natural products are highly stereodiversified and often provide highly specific biological activity, we screened a natural product library for inhibitors of TcTS and identified promising flavonoid and anthraquinone derivatives. A structure–activity relationship (SAR) analysis of the flavonoids revealed that apigenin had the minimal and sufficient structure for inhibition. Intriguingly, the compound has been reported to possess trypanocidal activity. An SAR analysis of anthraquinones showed that 6-chloro-9,10-dihydro-4,5,7-trihydroxy-9,10-dioxo-2-anthracenecarboxylic acid had the strongest inhibitory activity ever found against TcTS. Moreover, its inhibitory activity appeared to be specific to TcTS. These compounds may serve as potent lead chemotherapeutic scaffolds against Chagas’ disease." @default.
• W2078462004 created "2016-06-24" @default.
• W2078462004 creator A5027076116 @default.
• W2078462004 creator A5031009222 @default.
• W2078462004 creator A5039697896 @default.
• W2078462004 creator A5050723461 @default.
• W2078462004 creator A5060944562 @default.
• W2078462004 creator A5061571696 @default.
• W2078462004 creator A5065386696 @default.
• W2078462004 creator A5074428939 @default.
• W2078462004 date "2010-02-01" @default.
• W2078462004 modified "2023-10-12" @default.
• W2078462004 title "Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase" @default.
• W2078462004 cites W1524058052 @default.
• W2078462004 cites W1585347147 @default.
• W2078462004 cites W1968599630 @default.
• W2078462004 cites W1974722769 @default.
• W2078462004 cites W1987829448 @default.
• W2078462004 cites W1991001144 @default.
• W2078462004 cites W1995277355 @default.
• W2078462004 cites W2021217831 @default.
• W2078462004 cites W2031051359 @default.
• W2078462004 cites W2033610679 @default.
• W2078462004 cites W2044324768 @default.
• W2078462004 cites W2048589505 @default.
• W2078462004 cites W2052635995 @default.
• W2078462004 cites W2054259484 @default.
• W2078462004 cites W2062474897 @default.
• W2078462004 cites W2065077359 @default.
• W2078462004 cites W2071494279 @default.
• W2078462004 cites W2080576224 @default.
• W2078462004 cites W2085181735 @default.
• W2078462004 cites W2094566976 @default.
• W2078462004 cites W2103242123 @default.
• W2078462004 cites W2113889255 @default.
• W2078462004 cites W2123332780 @default.
• W2078462004 cites W2125782931 @default.
• W2078462004 cites W2126662293 @default.
• W2078462004 cites W2128581376 @default.
• W2078462004 cites W2135732933 @default.
• W2078462004 cites W2147474208 @default.
• W2078462004 cites W2147830473 @default.
• W2078462004 cites W2155159495 @default.
• W2078462004 cites W2162331245 @default.
• W2078462004 cites W2165956995 @default.
• W2078462004 cites W2168587587 @default.
• W2078462004 cites W2412606489 @default.
• W2078462004 cites W31096240 @default.
• W2078462004 cites W4211027594 @default.
• W2078462004 doi "https://doi.org/10.1016/j.bmc.2009.12.062" @default.
• W2078462004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20097567" @default.
• W2078462004 hasPublicationYear "2010" @default.
• W2078462004 type Work @default.
• W2078462004 sameAs 2078462004 @default.
• W2078462004 citedByCount "44" @default.
• W2078462004 countsByYear W20784620042012 @default.
• W2078462004 countsByYear W20784620042013 @default.
• W2078462004 countsByYear W20784620042014 @default.
• W2078462004 countsByYear W20784620042015 @default.
• W2078462004 countsByYear W20784620042016 @default.
• W2078462004 countsByYear W20784620042017 @default.
• W2078462004 countsByYear W20784620042018 @default.
• W2078462004 countsByYear W20784620042019 @default.
• W2078462004 countsByYear W20784620042020 @default.
• W2078462004 countsByYear W20784620042021 @default.
• W2078462004 countsByYear W20784620042022 @default.
• W2078462004 countsByYear W20784620042023 @default.
• W2078462004 crossrefType "journal-article" @default.
• W2078462004 hasAuthorship W2078462004A5027076116 @default.
• W2078462004 hasAuthorship W2078462004A5031009222 @default.
• W2078462004 hasAuthorship W2078462004A5039697896 @default.
• W2078462004 hasAuthorship W2078462004A5050723461 @default.
• W2078462004 hasAuthorship W2078462004A5060944562 @default.
• W2078462004 hasAuthorship W2078462004A5061571696 @default.
• W2078462004 hasAuthorship W2078462004A5065386696 @default.
• W2078462004 hasAuthorship W2078462004A5074428939 @default.
• W2078462004 hasConcept C112418997 @default.
• W2078462004 hasConcept C116073593 @default.
• W2078462004 hasConcept C134164806 @default.
• W2078462004 hasConcept C136764020 @default.
• W2078462004 hasConcept C150903083 @default.
• W2078462004 hasConcept C159047783 @default.
• W2078462004 hasConcept C181199279 @default.
• W2078462004 hasConcept C185592680 @default.
• W2078462004 hasConcept C193042331 @default.
• W2078462004 hasConcept C202751555 @default.
• W2078462004 hasConcept C207001950 @default.
• W2078462004 hasConcept C2776171842 @default.
• W2078462004 hasConcept C2777625466 @default.
• W2078462004 hasConcept C2777752497 @default.
• W2078462004 hasConcept C2778004101 @default.
• W2078462004 hasConcept C2778609962 @default.
• W2078462004 hasConcept C2779054382 @default.
• W2078462004 hasConcept C2779396153 @default.
• W2078462004 hasConcept C2780115458 @default.
• W2078462004 hasConcept C2780867653 @default.
• W2078462004 hasConcept C41008148 @default.
• W2078462004 hasConcept C55493867 @default.

• next