Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078467739> ?p ?o ?g. }
- W2078467739 endingPage "61" @default.
- W2078467739 startingPage "54" @default.
- W2078467739 abstract "Respiratory syncytial virus (RSV) infection has been associated to recurrent wheezing, but pathogenic mechanisms are unclear. Interleukin-4/Interleukin-13 (IL-4/IL-13) pathway is involved in both conditions. A common host genetic susceptibility may exist in patients whom RSV will trigger severe illness and those who develop recurrent wheezing.To assess, by a candidate-gene approach, whether genetic polymorphisms in IL-4/IL-13 pathway are associated with RSV infection severity and its outcome in Chilean children. A cohort of 118 RSV-infected infants was analyzed and followed for one year. Severity of acute infection and later recurrent wheezing were characterized. Alleles and genotypes frequencies were determined for two SNP in each of the genes IL-4, IL-13 and IL-4Rα. Association tests and interaction analyses were performed. Enrollment included 60 moderate and 58 severe cases. Two SNP were found associated to severity during acute infection in IL-4Rα gene (Gln551Arg, Ile50Val). The follow up was completed in 71% of patients (84/118). Later recurrent wheezing was 54% in severe group, versus 31% in moderate cases (p=0.035). In relation to outcome, allele Ile50 in IL-4Rα was more frequent in patients with moderate disease and no wheezing outcome. A common protector genotype is proposed for Chilean children: IL-4Rα Ile/Ile.Genetic variations in the host are associated to infection severity and outcome. A common genetic background might be influencing both pathologies." @default.
- W2078467739 created "2016-06-24" @default.
- W2078467739 creator A5001634339 @default.
- W2078467739 creator A5018340366 @default.
- W2078467739 creator A5022220953 @default.
- W2078467739 creator A5022371569 @default.
- W2078467739 creator A5033676198 @default.
- W2078467739 creator A5034780649 @default.
- W2078467739 creator A5042391875 @default.
- W2078467739 creator A5078772592 @default.
- W2078467739 date "2013-06-01" @default.
- W2078467739 modified "2023-10-06" @default.
- W2078467739 title "Respiratory syncytial virus infection and recurrent wheezing in Chilean infants: A genetic background?" @default.
- W2078467739 cites W1521605576 @default.
- W2078467739 cites W1546655027 @default.
- W2078467739 cites W1587881343 @default.
- W2078467739 cites W1964985824 @default.
- W2078467739 cites W1965075555 @default.
- W2078467739 cites W1978403205 @default.
- W2078467739 cites W1980556522 @default.
- W2078467739 cites W1982042604 @default.
- W2078467739 cites W1985178609 @default.
- W2078467739 cites W1986095162 @default.
- W2078467739 cites W1986189079 @default.
- W2078467739 cites W1986537717 @default.
- W2078467739 cites W1991878037 @default.
- W2078467739 cites W2000893752 @default.
- W2078467739 cites W2001005330 @default.
- W2078467739 cites W2004008925 @default.
- W2078467739 cites W2009114327 @default.
- W2078467739 cites W2013710564 @default.
- W2078467739 cites W2020074544 @default.
- W2078467739 cites W2026549082 @default.
- W2078467739 cites W2026801927 @default.
- W2078467739 cites W2028026535 @default.
- W2078467739 cites W2029220352 @default.
- W2078467739 cites W2035414819 @default.
- W2078467739 cites W2042709868 @default.
- W2078467739 cites W2048706280 @default.
- W2078467739 cites W2055912532 @default.
- W2078467739 cites W2057820649 @default.
- W2078467739 cites W2063260799 @default.
- W2078467739 cites W2068984152 @default.
- W2078467739 cites W2069631029 @default.
- W2078467739 cites W2078168327 @default.
- W2078467739 cites W2081041557 @default.
- W2078467739 cites W2083754122 @default.
- W2078467739 cites W2097384942 @default.
- W2078467739 cites W2106136941 @default.
- W2078467739 cites W2106514725 @default.
- W2078467739 cites W2110534539 @default.
- W2078467739 cites W2110547872 @default.
- W2078467739 cites W2110554565 @default.
- W2078467739 cites W2118102780 @default.
- W2078467739 cites W2118222136 @default.
- W2078467739 cites W2122696384 @default.
- W2078467739 cites W2130369696 @default.
- W2078467739 cites W2132088908 @default.
- W2078467739 cites W2133168241 @default.
- W2078467739 cites W2134466274 @default.
- W2078467739 cites W2136941346 @default.
- W2078467739 cites W2140005369 @default.
- W2078467739 cites W2140981885 @default.
- W2078467739 cites W2141468081 @default.
- W2078467739 cites W2143014879 @default.
- W2078467739 cites W2144410539 @default.
- W2078467739 cites W2145783587 @default.
- W2078467739 cites W2146101869 @default.
- W2078467739 cites W2146536283 @default.
- W2078467739 cites W2147516417 @default.
- W2078467739 cites W2152238867 @default.
- W2078467739 cites W2154460881 @default.
- W2078467739 cites W2154953845 @default.
- W2078467739 cites W2156733904 @default.
- W2078467739 cites W2167717072 @default.
- W2078467739 cites W2169590985 @default.
- W2078467739 cites W2312397711 @default.
- W2078467739 cites W4211037481 @default.
- W2078467739 cites W4313347695 @default.
- W2078467739 doi "https://doi.org/10.1016/j.meegid.2012.12.030" @default.
- W2078467739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23333336" @default.
- W2078467739 hasPublicationYear "2013" @default.
- W2078467739 type Work @default.
- W2078467739 sameAs 2078467739 @default.
- W2078467739 citedByCount "12" @default.
- W2078467739 countsByYear W20784677392015 @default.
- W2078467739 countsByYear W20784677392017 @default.
- W2078467739 countsByYear W20784677392018 @default.
- W2078467739 countsByYear W20784677392019 @default.
- W2078467739 countsByYear W20784677392020 @default.
- W2078467739 countsByYear W20784677392021 @default.
- W2078467739 countsByYear W20784677392022 @default.
- W2078467739 crossrefType "journal-article" @default.
- W2078467739 hasAuthorship W2078467739A5001634339 @default.
- W2078467739 hasAuthorship W2078467739A5018340366 @default.
- W2078467739 hasAuthorship W2078467739A5022220953 @default.
- W2078467739 hasAuthorship W2078467739A5022371569 @default.
- W2078467739 hasAuthorship W2078467739A5033676198 @default.