Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078468127> ?p ?o ?g. }
- W2078468127 endingPage "406" @default.
- W2078468127 startingPage "393" @default.
- W2078468127 abstract "Hepatocellular carcinoma (HCC) is the third leading cause of cancer death, and its incidence is increasing worldwide in an alarming manner. The development of curative therapy for advanced and metastatic HCC is a high clinical priority. The HCC genome is complex and heterogeneous; therefore, the identification of recurrent genomic and related gene alterations is critical for developing clinical applications for diagnosis, prognosis and targeted therapy of the disease. This article focuses on recent research progress and our contribution in identifying and deciphering the role of defined genetic alterations in the pathogenesis of HCC. A significant number of genes that promote or suppress HCC cell growth have been identified at the sites of genomic reorganization. Notwithstanding the accumulation of multiple genetic alterations, highly recurrent changes on a single chromosome can alter the expression of oncogenes and tumor suppressor genes (TSGs) whose deregulation may be sufficient to drive the progression of normal hepatocytes to malignancy. A distinct and highly recurrent pattern of genomic imbalances in HCC includes the loss of DNA copy number (associated with loss of heterozygosity) of TSG-containing chromosome 8p and gain of DNA copy number or regional amplification of protooncogenes on chromosome 8q. Even though 8p is relatively small, it carries an unusually large number of TSGs, while, on the other side, several oncogenes are dispersed along 8q. Compelling evidence demonstrates that DLC1, a potent TSG on 8p, and MYC oncogene on 8q play a critical role in the pathogenesis of human HCC. Direct evidence for their role in the genesis of HCC has been obtained in a mosaic mouse model. Knockdown of DLC1 helps MYC in the induction of hepatoblast transformation in vitro, and in the development of HCC in vivo. Therapeutic interventions, which would simultaneously target signaling pathways governing both DLC1 and MYC functions in hepatocarcinogenesis, could result in progress in the treatment of liver cancer." @default.
- W2078468127 created "2016-06-24" @default.
- W2078468127 creator A5046853064 @default.
- W2078468127 creator A5047866788 @default.
- W2078468127 date "2012-05-10" @default.
- W2078468127 modified "2023-09-28" @default.
- W2078468127 title "Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: Potential prospects for combined targeted therapeutics" @default.
- W2078468127 cites W1522000767 @default.
- W2078468127 cites W1556926745 @default.
- W2078468127 cites W1565545213 @default.
- W2078468127 cites W1778078277 @default.
- W2078468127 cites W1839381104 @default.
- W2078468127 cites W187705992 @default.
- W2078468127 cites W1963780296 @default.
- W2078468127 cites W1965254413 @default.
- W2078468127 cites W1966413757 @default.
- W2078468127 cites W1966803025 @default.
- W2078468127 cites W1967174073 @default.
- W2078468127 cites W1968831951 @default.
- W2078468127 cites W1970060716 @default.
- W2078468127 cites W1970376429 @default.
- W2078468127 cites W1971837077 @default.
- W2078468127 cites W1972856645 @default.
- W2078468127 cites W1973267581 @default.
- W2078468127 cites W1976774425 @default.
- W2078468127 cites W1977062284 @default.
- W2078468127 cites W1978054377 @default.
- W2078468127 cites W1979579868 @default.
- W2078468127 cites W1980751371 @default.
- W2078468127 cites W1982761958 @default.
- W2078468127 cites W1984736192 @default.
- W2078468127 cites W1985000689 @default.
- W2078468127 cites W1985166341 @default.
- W2078468127 cites W1986218484 @default.
- W2078468127 cites W1991805448 @default.
- W2078468127 cites W1994054099 @default.
- W2078468127 cites W1996564274 @default.
- W2078468127 cites W1997122579 @default.
- W2078468127 cites W1997945905 @default.
- W2078468127 cites W1998817605 @default.
- W2078468127 cites W2001269102 @default.
- W2078468127 cites W2001385291 @default.
- W2078468127 cites W2001756777 @default.
- W2078468127 cites W2002668822 @default.
- W2078468127 cites W2004275852 @default.
- W2078468127 cites W2004871370 @default.
- W2078468127 cites W2005396649 @default.
- W2078468127 cites W2008945738 @default.
- W2078468127 cites W2016267459 @default.
- W2078468127 cites W2017194914 @default.
- W2078468127 cites W2020352533 @default.
- W2078468127 cites W2020575206 @default.
- W2078468127 cites W2025945283 @default.
- W2078468127 cites W2027345413 @default.
- W2078468127 cites W2031562284 @default.
- W2078468127 cites W2032599100 @default.
- W2078468127 cites W2035302891 @default.
- W2078468127 cites W2035643930 @default.
- W2078468127 cites W2037032898 @default.
- W2078468127 cites W203927818 @default.
- W2078468127 cites W2046853446 @default.
- W2078468127 cites W2048410884 @default.
- W2078468127 cites W2049659810 @default.
- W2078468127 cites W2049685139 @default.
- W2078468127 cites W2050281373 @default.
- W2078468127 cites W2054365538 @default.
- W2078468127 cites W2054657650 @default.
- W2078468127 cites W2056339293 @default.
- W2078468127 cites W2058309856 @default.
- W2078468127 cites W2061429557 @default.
- W2078468127 cites W2062629274 @default.
- W2078468127 cites W2063430881 @default.
- W2078468127 cites W2064906213 @default.
- W2078468127 cites W2066637671 @default.
- W2078468127 cites W2067212761 @default.
- W2078468127 cites W2067931945 @default.
- W2078468127 cites W2069142607 @default.
- W2078468127 cites W2069892639 @default.
- W2078468127 cites W2071018921 @default.
- W2078468127 cites W2071811821 @default.
- W2078468127 cites W2071918743 @default.
- W2078468127 cites W2072200968 @default.
- W2078468127 cites W2073101093 @default.
- W2078468127 cites W2075184035 @default.
- W2078468127 cites W2076406046 @default.
- W2078468127 cites W2076909501 @default.
- W2078468127 cites W2078885340 @default.
- W2078468127 cites W2078988248 @default.
- W2078468127 cites W2080146774 @default.
- W2078468127 cites W2081241334 @default.
- W2078468127 cites W2084268608 @default.
- W2078468127 cites W2084780592 @default.
- W2078468127 cites W2087121423 @default.
- W2078468127 cites W2087683535 @default.
- W2078468127 cites W2088629624 @default.
- W2078468127 cites W2089017266 @default.
- W2078468127 cites W2090323833 @default.
- W2078468127 cites W2091045065 @default.