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- W2078468596 abstract "The measurement of interstitial fluid hydrostatic pressure by means of the rigid perforated capsule method proposed by Guyton [Guyton, A. C. (1963). Circ. Res. 12, 399–414] has been criticized as yielding pressures which are sensitive to transcapsular protein oncotic gradients. These gradients are due to the protein excluding characteristics of the dense granulation tissue which grows inside and around the capsules. In addition, the waiting periods necessary to achieve steady-state pressures following maneuvers are often longer than the ability of the interstitial space to remain stable. A modification of the capsule method which might meet both criticisms employs hollow capsules made of porous polyethylene which does not appear to induce the growth of granulation tissue. We tested these chronically implanted capsules for their protein gradient sensitivity by substituting varying concentrations of protein into their interiors with an intentional brief elevation of pressure past the “breaking point” of interstitial tissue. After 1 min, the pressure decay characteristics and final steady-state values of pressure were recorded and correlated to the injectate protein concentration. There was no relationship between any of these parameters and the level of capsular protein. It was concluded that these capsules are not significantly sensitive to transcapsular protein gradients, are quickly responsive, are demonstrably in communication with the surrounding interstitium, and are thus suitable for measurement of interstitial fluid hydrostatic pressure. For canine gastrocnemius muscle, the mean steady-state pressure (N = 38) was 6.4 ± 0.5 (SEM) mm Hg, and for the skin (N = 29) was 1.5 ± 0.4 mm Hg." @default.
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- W2078468596 date "1978-11-01" @default.
- W2078468596 modified "2023-10-16" @default.
- W2078468596 title "Validity of interstitial fluid hydrostatic pressure measurement in hollow porous polyethylene capsules" @default.
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- W2078468596 doi "https://doi.org/10.1016/0026-2862(78)90065-1" @default.
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