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• W2078473937 abstract "The kidney is responsible for regulation of water and electrolyte balance, filtration and absorption of plasma proteins, and control of blood volume and pressure. Homeostasis achieved by the kidney is controlled in large part by the action of hormones or proteins on specific transmembrane receptors. Conversely, many renal diseases, including that resulting from atherosclerosis, are characterised by scarring and abnormal proliferation of cellular components of the kidney, and these processes are mediated in large part by these same receptors. The G protein–coupled receptors constitute a large and diverse class of proteins, characterised by the possession of seven transmembrane-spanning domains. These receptors bind polypeptide growth factors, which function to transmit a variety of signals from the extracellular to the intracellular milieu. The receptor-associated G proteins utilised by the kidney derive their specificity not only by activating or inhibiting various second-messenger molecules, but also by their location on particular cell types. In this review, several G protein–coupled receptors will be discussed from the perspective of their importance to kidney function and to the pathogenesis of renal disease, atherosclerosis, and hypertension." @default.
• W2078473937 created "2016-06-24" @default.
• W2078473937 creator A5054972531 @default.
• W2078473937 date "1998-05-01" @default.
• W2078473937 modified "2023-10-18" @default.
• W2078473937 title "G Protein–Coupled Receptor Signalling in the Kidney" @default.
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• W2078473937 doi "https://doi.org/10.1016/s0898-6568(97)00137-x" @default.
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• W2078473937 hasPublicationYear "1998" @default.
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