FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078474080> ?p ?o ?g. }

• W2078474080 endingPage "327" @default.
• W2078474080 startingPage "316" @default.
• W2078474080 abstract "The cytoplasmic domain of the HIV-1 Env glycoprotein (gp41) contains sequences that affect the trafficking of Env within the host cell. We previously showed that the membrane-proximal tyrosine-based adaptor protein (AP)-binding signal of gp41 (Y712XXL) is required for optimal viral infectivity and entry into target cells. Because these effects were not attributable to an effect on the incorporation of Env into virions, we hypothesized that they involved targeting of viral assembly to specific endosomal membranes that conferred greater fusogenicity. To further elaborate this hypothesis, we mutated the C-terminal leucine-based AP-binding signal of gp41 (LL855/856). In contrast to Env Y712, the leucine signal was dispensable for viral infectivity in both single cycle assays and during spreading infections within cultures of peripheral blood mononuclear cells (PBMCs). To test the hypothesis that these AP-binding motifs target Env to endosomes during viral morphogenesis, we compared the subcellular localization of wild-type Env to mutants of the Y712 and LL855/856 signals. The results failed to support the hypothesis that these signals target viral assembly to specific endosomal membranes. Strikingly, in the context of a C2-V3 region that confers macrophage-tropism, mutation of Y712 no longer markedly affected viral infectivity in either single cycle assays or during spreading infection within PBMCs, and it did not impair viral entry. These data indicate that the importance of the tyrosine-based sorting signal in gp41 for optimal viral infectivity depends on sequences in gp120. This observation is consistent with the hypothesis that the Y712 residue is part of the ectodomain of gp41 in virion-associated Env. We speculate that as part of the ectodomain, Y712 could affect specifically the conformation of the more positively charged CXCR4-tropic V3 loop in a manner that augments viral fusogenicity and infectivity." @default.
• W2078474080 created "2016-06-24" @default.
• W2078474080 creator A5003180156 @default.
• W2078474080 creator A5074397767 @default.
• W2078474080 creator A5081531938 @default.
• W2078474080 date "2006-10-01" @default.
• W2078474080 modified "2023-09-29" @default.
• W2078474080 title "The effect of the membrane-proximal tyrosine-based sorting signal of HIV-1 gp41 on viral infectivity depends on sequences within gp120" @default.
• W2078474080 cites W1580210412 @default.
• W2078474080 cites W1632486555 @default.
• W2078474080 cites W1953822958 @default.
• W2078474080 cites W1974566426 @default.
• W2078474080 cites W1986684027 @default.
• W2078474080 cites W1991663757 @default.
• W2078474080 cites W1995968087 @default.
• W2078474080 cites W1996639027 @default.
• W2078474080 cites W2009205890 @default.
• W2078474080 cites W2014970708 @default.
• W2078474080 cites W2019469658 @default.
• W2078474080 cites W2021500400 @default.
• W2078474080 cites W2023916724 @default.
• W2078474080 cites W2027458871 @default.
• W2078474080 cites W2034399323 @default.
• W2078474080 cites W2034608470 @default.
• W2078474080 cites W2034988569 @default.
• W2078474080 cites W2042471523 @default.
• W2078474080 cites W2053584325 @default.
• W2078474080 cites W2054525948 @default.
• W2078474080 cites W2057442484 @default.
• W2078474080 cites W2058032164 @default.
• W2078474080 cites W2059974481 @default.
• W2078474080 cites W2099491605 @default.
• W2078474080 cites W2124967749 @default.
• W2078474080 cites W2132138777 @default.
• W2078474080 cites W2156010727 @default.
• W2078474080 cites W2157786784 @default.
• W2078474080 cites W2162183496 @default.
• W2078474080 cites W2168907718 @default.
• W2078474080 doi "https://doi.org/10.1016/j.virol.2006.06.023" @default.
• W2078474080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16905171" @default.
• W2078474080 hasPublicationYear "2006" @default.
• W2078474080 type Work @default.
• W2078474080 sameAs 2078474080 @default.
• W2078474080 citedByCount "11" @default.
• W2078474080 countsByYear W20784740802013 @default.
• W2078474080 countsByYear W20784740802014 @default.
• W2078474080 countsByYear W20784740802015 @default.
• W2078474080 countsByYear W20784740802018 @default.
• W2078474080 crossrefType "journal-article" @default.
• W2078474080 hasAuthorship W2078474080A5003180156 @default.
• W2078474080 hasAuthorship W2078474080A5074397767 @default.
• W2078474080 hasAuthorship W2078474080A5081531938 @default.
• W2078474080 hasBestOaLocation W20784740801 @default.
• W2078474080 hasConcept C102747710 @default.
• W2078474080 hasConcept C106358424 @default.
• W2078474080 hasConcept C108625454 @default.
• W2078474080 hasConcept C140704245 @default.
• W2078474080 hasConcept C153911025 @default.
• W2078474080 hasConcept C159047783 @default.
• W2078474080 hasConcept C159654299 @default.
• W2078474080 hasConcept C195616568 @default.
• W2078474080 hasConcept C2522874641 @default.
• W2078474080 hasConcept C2776165026 @default.
• W2078474080 hasConcept C2776258796 @default.
• W2078474080 hasConcept C35693153 @default.
• W2078474080 hasConcept C54355233 @default.
• W2078474080 hasConcept C55493867 @default.
• W2078474080 hasConcept C58475186 @default.
• W2078474080 hasConcept C79879829 @default.
• W2078474080 hasConcept C86803240 @default.
• W2078474080 hasConcept C95444343 @default.
• W2078474080 hasConcept C97380033 @default.
• W2078474080 hasConceptScore W2078474080C102747710 @default.
• W2078474080 hasConceptScore W2078474080C106358424 @default.
• W2078474080 hasConceptScore W2078474080C108625454 @default.
• W2078474080 hasConceptScore W2078474080C140704245 @default.
• W2078474080 hasConceptScore W2078474080C153911025 @default.
• W2078474080 hasConceptScore W2078474080C159047783 @default.
• W2078474080 hasConceptScore W2078474080C159654299 @default.
• W2078474080 hasConceptScore W2078474080C195616568 @default.
• W2078474080 hasConceptScore W2078474080C2522874641 @default.
• W2078474080 hasConceptScore W2078474080C2776165026 @default.
• W2078474080 hasConceptScore W2078474080C2776258796 @default.
• W2078474080 hasConceptScore W2078474080C35693153 @default.
• W2078474080 hasConceptScore W2078474080C54355233 @default.
• W2078474080 hasConceptScore W2078474080C55493867 @default.
• W2078474080 hasConceptScore W2078474080C58475186 @default.
• W2078474080 hasConceptScore W2078474080C79879829 @default.
• W2078474080 hasConceptScore W2078474080C86803240 @default.
• W2078474080 hasConceptScore W2078474080C95444343 @default.
• W2078474080 hasConceptScore W2078474080C97380033 @default.
• W2078474080 hasIssue "2" @default.
• W2078474080 hasLocation W20784740801 @default.
• W2078474080 hasLocation W20784740802 @default.
• W2078474080 hasOpenAccess W2078474080 @default.
• W2078474080 hasPrimaryLocation W20784740801 @default.
• W2078474080 hasRelatedWork W1521884339 @default.
• W2078474080 hasRelatedWork W176140375 @default.

• next