FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078475650> ?p ?o ?g. }

• W2078475650 endingPage "162" @default.
• W2078475650 startingPage "155" @default.
• W2078475650 abstract "The presence of inositol 1,4,5-trisphosphate (IP3) receptors in human myometrium has been investigated and their concentration compared with that of oxytocin receptors. Myometrial microsomes were incubated with 3H-IP3 alone and in the presence of unlabeled IP3. Binding was to a single class of noninteracting sites with a density of 1-2 pmol/mg of protein. The sites had characteristics of true IP3 receptors, i.e., very fast association and dissociation rates, high affinity (Kd 25- 50 nM) and specificity (IP3 > IP3[2,4,5], IP4 ≫ IP5 > IP3[1,3,4], IP1, IP2, IP6), and did not metabolize 3H-IP3. The binding was maximal at pH 8, and was inhibited by calcium (IC50 = 80 nM), magnesium (IC50 = 100 μM), heparin (IC50 = 4.5 μ/ml), and GTP (IC50 = 150 μM). The concentration and affinity of IP3 receptors were similar in pregnant and nonpregnant myometrium and remained constant during labor. By contrast, the density of oxytocin receptor increased significantly from nonpregnant to pregnant tissue and fell in advanced spontaneous labor but not in advanced induced labor. These results provide new, additional evidence for the involvement of the phosphatidylinositol pathway in the control of uterine contractility. (Endocrinology127: 155–162,1990)" @default.
• W2078475650 created "2016-06-24" @default.
• W2078475650 creator A5032775258 @default.
• W2078475650 creator A5047936186 @default.
• W2078475650 creator A5057799772 @default.
• W2078475650 creator A5089942283 @default.
• W2078475650 date "1990-07-01" @default.
• W2078475650 modified "2023-10-18" @default.
• W2078475650 title "Inositol 1,4,5-Trisphosphate and Oxytocin Binding in Human Myometrium*" @default.
• W2078475650 cites W1436501061 @default.
• W2078475650 cites W1495233477 @default.
• W2078475650 cites W1496902535 @default.
• W2078475650 cites W1512804327 @default.
• W2078475650 cites W1523078822 @default.
• W2078475650 cites W1564829038 @default.
• W2078475650 cites W1575979011 @default.
• W2078475650 cites W1597778600 @default.
• W2078475650 cites W166149822 @default.
• W2078475650 cites W1676765468 @default.
• W2078475650 cites W190697756 @default.
• W2078475650 cites W1983649348 @default.
• W2078475650 cites W1983942830 @default.
• W2078475650 cites W1992040551 @default.
• W2078475650 cites W1992679879 @default.
• W2078475650 cites W1994002391 @default.
• W2078475650 cites W2006050008 @default.
• W2078475650 cites W2008684161 @default.
• W2078475650 cites W2022429630 @default.
• W2078475650 cites W2039905246 @default.
• W2078475650 cites W2043131911 @default.
• W2078475650 cites W2072376575 @default.
• W2078475650 cites W2080127362 @default.
• W2078475650 cites W2086230588 @default.
• W2078475650 cites W2090839129 @default.
• W2078475650 cites W2128635872 @default.
• W2078475650 cites W2136189765 @default.
• W2078475650 cites W2169830226 @default.
• W2078475650 cites W2245657173 @default.
• W2078475650 cites W303363201 @default.
• W2078475650 doi "https://doi.org/10.1210/endo-127-1-155" @default.
• W2078475650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2163308" @default.
• W2078475650 hasPublicationYear "1990" @default.
• W2078475650 type Work @default.
• W2078475650 sameAs 2078475650 @default.
• W2078475650 citedByCount "38" @default.
• W2078475650 countsByYear W20784756502012 @default.
• W2078475650 countsByYear W20784756502013 @default.
• W2078475650 countsByYear W20784756502016 @default.
• W2078475650 countsByYear W20784756502017 @default.
• W2078475650 countsByYear W20784756502018 @default.
• W2078475650 countsByYear W20784756502019 @default.
• W2078475650 crossrefType "journal-article" @default.
• W2078475650 hasAuthorship W2078475650A5032775258 @default.
• W2078475650 hasAuthorship W2078475650A5047936186 @default.
• W2078475650 hasAuthorship W2078475650A5057799772 @default.
• W2078475650 hasAuthorship W2078475650A5089942283 @default.
• W2078475650 hasConcept C126322002 @default.
• W2078475650 hasConcept C134018914 @default.
• W2078475650 hasConcept C152624196 @default.
• W2078475650 hasConcept C170493617 @default.
• W2078475650 hasConcept C181612422 @default.
• W2078475650 hasConcept C185592680 @default.
• W2078475650 hasConcept C2776176026 @default.
• W2078475650 hasConcept C2776766599 @default.
• W2078475650 hasConcept C2777427919 @default.
• W2078475650 hasConcept C2778164554 @default.
• W2078475650 hasConcept C2778618036 @default.
• W2078475650 hasConcept C2779066055 @default.
• W2078475650 hasConcept C2780610907 @default.
• W2078475650 hasConcept C2781387506 @default.
• W2078475650 hasConcept C39133596 @default.
• W2078475650 hasConcept C55493867 @default.
• W2078475650 hasConcept C62478195 @default.
• W2078475650 hasConcept C71924100 @default.
• W2078475650 hasConcept C74998103 @default.
• W2078475650 hasConcept C86803240 @default.
• W2078475650 hasConceptScore W2078475650C126322002 @default.
• W2078475650 hasConceptScore W2078475650C134018914 @default.
• W2078475650 hasConceptScore W2078475650C152624196 @default.
• W2078475650 hasConceptScore W2078475650C170493617 @default.
• W2078475650 hasConceptScore W2078475650C181612422 @default.
• W2078475650 hasConceptScore W2078475650C185592680 @default.
• W2078475650 hasConceptScore W2078475650C2776176026 @default.
• W2078475650 hasConceptScore W2078475650C2776766599 @default.
• W2078475650 hasConceptScore W2078475650C2777427919 @default.
• W2078475650 hasConceptScore W2078475650C2778164554 @default.
• W2078475650 hasConceptScore W2078475650C2778618036 @default.
• W2078475650 hasConceptScore W2078475650C2779066055 @default.
• W2078475650 hasConceptScore W2078475650C2780610907 @default.
• W2078475650 hasConceptScore W2078475650C2781387506 @default.
• W2078475650 hasConceptScore W2078475650C39133596 @default.
• W2078475650 hasConceptScore W2078475650C55493867 @default.
• W2078475650 hasConceptScore W2078475650C62478195 @default.
• W2078475650 hasConceptScore W2078475650C71924100 @default.
• W2078475650 hasConceptScore W2078475650C74998103 @default.
• W2078475650 hasConceptScore W2078475650C86803240 @default.
• W2078475650 hasIssue "1" @default.
• W2078475650 hasLocation W20784756501 @default.

• next