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- W2078475877 abstract "The synthesis and biological evaluation of Z- and E-1-methyl-2-(1-hydroximinoethyl)-6-methoxy-3,4-dihydro-naphthalene (Z-1 and E-1) as nonsteroidal inhibitors of 17α-hydroxylase-C17,20-lyase (P450 17, CYP17) is described. Z-1 and E-1 were separated by column chromatography and identified by 1H NMR. The synthesis of the key compound 3 was accomplished by a new reaction acetylating the 1-methyl-6-methoxy-3,4-dihydronaphthalene compound 2 under Friedel-Crafts conditions. Compound 2 was obtained from the 1-tetralone via Wittig reaction. Using a microsomal fraction of human testicular enzyme, Z-1 and E-1 inhibited the target enzyme only marginally." @default.
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- W2078475877 date "1997-01-01" @default.
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- W2078475877 title "Synthesis ofZ- andE-1-Methyl-2-(1-hydroximinoethyl)-6-methoxy-3,4-dihydronaphthalene and Evaluation as Inhibitors of 17α-Hydroxylase-C17,20-Lyase (P450 17)" @default.
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- W2078475877 doi "https://doi.org/10.1002/ardp.19973301108" @default.
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