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- W2078477918 abstract "IN 1977, we first reported the antiarrhythmic effect of imipramine hydrochloride.<sup>1</sup>Prior to that time, physicians generally believed that the tricyclic antidepressants (TCAs) caused arrhythmia. That belief stemmed from the propensity of overdoses of these drugs to provoke arrhythmias.<sup>2</sup>However, it subsequently became apparent, both from our studies<sup>3-6</sup>and the work of others,<sup>7</sup>that at plasma concentrations therapeutic for depression,<sup>8</sup>TCAs suppress arrhythmias, and their cardiac effects closely resemble those of class I antiarrhythmic drugs.<sup>9,10</sup>Until recently, it was our belief that depressed patients with preexisting arrhythmias would benefit from the antiarrhythmic effect of TCAs.<sup>11,12</sup>Unfortunately, recent studies indicate that this opinion may need to be revised. Ventricular premature depolarizations (VPDs) are a well-documented risk factor for sudden death after myocardial infarction (MI)<sup>13,14</sup>and the assumption had been that drugs that suppress VPDs would reduce this associated mortality. However, in 1983, Furberg" @default.
- W2078477918 created "2016-06-24" @default.
- W2078477918 creator A5030196806 @default.
- W2078477918 date "1993-05-26" @default.
- W2078477918 modified "2023-09-29" @default.
- W2078477918 title "The Safety of Tricyclic Antidepressants in Cardiac Patients" @default.
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- W2078477918 doi "https://doi.org/10.1001/jama.1993.03500200087039" @default.
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