FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078478844> ?p ?o ?g. }

• W2078478844 endingPage "978" @default.
• W2078478844 startingPage "965" @default.
• W2078478844 abstract "The recently published WHO/FAO guidelines on the assessment of allergenicity of novel food proteins provide a strategy with which to approach the determination of the potential of novel proteins in foods to be allergens. Key to this strategy are the assessment of sequence similarity to known allergens and the assessment of the resistance to pepsin hydrolysis. Ice structuring proteins (also commonly referred to as anti-freeze or thermal hysteresis proteins) are a group of naturally occurring proteins that bind to ice and structure ice crystal formation. The amino acid sequence of the ice structuring protein (ISP) type III HPLC 12 (ISP type III) was compared in silico with the sequences of known allergens. Secondly, the resistance to pepsin hydrolysis of ISP type III and its glycoconjugates (produced in recombinant baker's yeast) was assessed. The results indicate that ISP type III has no sequence similarity with known allergenic proteins. Both ISP type III and ISP type III glycoconjugates contained within the fermentation product were hydrolysed readily by pepsin (50% loss in <10 min at pH 1.5) to give peptide fragments that were too small to be allergenic or to trigger cross-linking to IgE. In an accompanying study, we demonstrated that IgE from fish-allergic individuals did not bind ISP Type III. Therefore, in accordance with the WHO/FAO strategy, the assessment of ISP type III and ISP type III glycoconjugates by sequence analysis together with lack of resistance to pepsin hydrolysis and the absence of IgE binding supports the conclusion that both are unlikely to present a potential sensitisation hazard." @default.
• W2078478844 created "2016-06-24" @default.
• W2078478844 creator A5000725210 @default.
• W2078478844 creator A5028645980 @default.
• W2078478844 creator A5032042548 @default.
• W2078478844 creator A5033385015 @default.
• W2078478844 creator A5049201884 @default.
• W2078478844 creator A5084106287 @default.
• W2078478844 date "2002-07-01" @default.
• W2078478844 modified "2023-10-16" @default.
• W2078478844 title "Sequence analysis and resistance to pepsin hydrolysis as part of an assessment of the potential allergenicity of ice structuring protein type III HPLC 12" @default.
• W2078478844 cites W1851792052 @default.
• W2078478844 cites W1961219082 @default.
• W2078478844 cites W1967594771 @default.
• W2078478844 cites W1973776145 @default.
• W2078478844 cites W1974078294 @default.
• W2078478844 cites W1974720495 @default.
• W2078478844 cites W1975085160 @default.
• W2078478844 cites W1982405838 @default.
• W2078478844 cites W1982994228 @default.
• W2078478844 cites W1997894129 @default.
• W2078478844 cites W2004364394 @default.
• W2078478844 cites W2024109758 @default.
• W2078478844 cites W2026779994 @default.
• W2078478844 cites W2044650616 @default.
• W2078478844 cites W2044819171 @default.
• W2078478844 cites W2065504830 @default.
• W2078478844 cites W2068630820 @default.
• W2078478844 cites W2071993487 @default.
• W2078478844 cites W2092316554 @default.
• W2078478844 cites W2094191976 @default.
• W2078478844 cites W2119908538 @default.
• W2078478844 cites W2120015448 @default.
• W2078478844 cites W2139517791 @default.
• W2078478844 cites W2151845811 @default.
• W2078478844 cites W4244824827 @default.
• W2078478844 doi "https://doi.org/10.1016/s0278-6915(02)00100-x" @default.
• W2078478844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12065219" @default.
• W2078478844 hasPublicationYear "2002" @default.
• W2078478844 type Work @default.
• W2078478844 sameAs 2078478844 @default.
• W2078478844 citedByCount "25" @default.
• W2078478844 countsByYear W20784788442013 @default.
• W2078478844 countsByYear W20784788442014 @default.
• W2078478844 countsByYear W20784788442019 @default.
• W2078478844 countsByYear W20784788442020 @default.
• W2078478844 countsByYear W20784788442022 @default.
• W2078478844 countsByYear W20784788442023 @default.
• W2078478844 crossrefType "journal-article" @default.
• W2078478844 hasAuthorship W2078478844A5000725210 @default.
• W2078478844 hasAuthorship W2078478844A5028645980 @default.
• W2078478844 hasAuthorship W2078478844A5032042548 @default.
• W2078478844 hasAuthorship W2078478844A5033385015 @default.
• W2078478844 hasAuthorship W2078478844A5049201884 @default.
• W2078478844 hasAuthorship W2078478844A5084106287 @default.
• W2078478844 hasConcept C10010492 @default.
• W2078478844 hasConcept C104317684 @default.
• W2078478844 hasConcept C16311235 @default.
• W2078478844 hasConcept C167625842 @default.
• W2078478844 hasConcept C181199279 @default.
• W2078478844 hasConcept C185592680 @default.
• W2078478844 hasConcept C40767141 @default.
• W2078478844 hasConcept C552990157 @default.
• W2078478844 hasConcept C55493867 @default.
• W2078478844 hasConcept C61053724 @default.
• W2078478844 hasConcept C94412978 @default.
• W2078478844 hasConceptScore W2078478844C10010492 @default.
• W2078478844 hasConceptScore W2078478844C104317684 @default.
• W2078478844 hasConceptScore W2078478844C16311235 @default.
• W2078478844 hasConceptScore W2078478844C167625842 @default.
• W2078478844 hasConceptScore W2078478844C181199279 @default.
• W2078478844 hasConceptScore W2078478844C185592680 @default.
• W2078478844 hasConceptScore W2078478844C40767141 @default.
• W2078478844 hasConceptScore W2078478844C552990157 @default.
• W2078478844 hasConceptScore W2078478844C55493867 @default.
• W2078478844 hasConceptScore W2078478844C61053724 @default.
• W2078478844 hasConceptScore W2078478844C94412978 @default.
• W2078478844 hasIssue "7" @default.
• W2078478844 hasLocation W20784788441 @default.
• W2078478844 hasLocation W20784788442 @default.
• W2078478844 hasOpenAccess W2078478844 @default.
• W2078478844 hasPrimaryLocation W20784788441 @default.
• W2078478844 hasRelatedWork W150090254 @default.
• W2078478844 hasRelatedWork W1965617697 @default.
• W2078478844 hasRelatedWork W1975836822 @default.
• W2078478844 hasRelatedWork W2011602722 @default.
• W2078478844 hasRelatedWork W2024383575 @default.
• W2078478844 hasRelatedWork W2053028024 @default.
• W2078478844 hasRelatedWork W2352822564 @default.
• W2078478844 hasRelatedWork W2978022857 @default.
• W2078478844 hasRelatedWork W3140797161 @default.
• W2078478844 hasRelatedWork W209500849 @default.
• W2078478844 hasVolume "40" @default.
• W2078478844 isParatext "false" @default.
• W2078478844 isRetracted "false" @default.
• W2078478844 magId "2078478844" @default.
• W2078478844 workType "article" @default.