FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078482635> ?p ?o ?g. }

• W2078482635 endingPage "5948" @default.
• W2078482635 startingPage "5943" @default.
• W2078482635 abstract "CD4(+) helper T (Th) cells differentiate toward distinct effector cell lineages characterized by their distinct cytokine expression patterns and functions. Multiple Th cell populations secrete IL-22 that contributes to both protective and pathological inflammatory responses. Although the differentiation of IL-22-producing Th cells is controlled by the aryl hydrocarbon receptor (AhR), little is known about the regulatory mechanisms inducing physiological stimulators for AhR. Here, we show that Notch signaling enhances IL-22 production by CD4(+) T cells by a mechanism involving AhR stimulation. Notch-mediated stimulation of CD4(+) T cells increased the production of IL-22 even in the absence of STAT3. CD4(+) T cells from RBP-J-deficient mice had little ability to produce IL-22 through T cell receptor-mediated stimulation. RBP-J-deficient mice were highly susceptible to the detrimental immunopathology associated with ConA-induced hepatitis with little IL-22 production by CD4(+) T cells. Exogenous IL-22 protected RBP-J-deficient mice from ConA-induced hepatitis. Notch signaling promoted production of endogenous stimulators for AhR, which further augmented IL-22 secretion. Our studies identify a Notch-AhR axis that regulates IL-22 expression and fine-tunes immune system control of inflammatory responses." @default.
• W2078482635 created "2016-06-24" @default.
• W2078482635 creator A5001884814 @default.
• W2078482635 creator A5059554216 @default.
• W2078482635 creator A5070727803 @default.
• W2078482635 creator A5074188154 @default.
• W2078482635 creator A5083297478 @default.
• W2078482635 creator A5085603605 @default.
• W2078482635 creator A5087850032 @default.
• W2078482635 date "2010-03-15" @default.
• W2078482635 modified "2023-10-10" @default.
• W2078482635 title "Notch signaling drives IL-22 secretion in CD4⁺T cells by stimulating the aryl hydrocarbon receptor" @default.
• W2078482635 cites W1750541350 @default.
• W2078482635 cites W1900386759 @default.
• W2078482635 cites W1964052073 @default.
• W2078482635 cites W1966530387 @default.
• W2078482635 cites W1972140301 @default.
• W2078482635 cites W1978615362 @default.
• W2078482635 cites W1980854526 @default.
• W2078482635 cites W1993003564 @default.
• W2078482635 cites W2004186675 @default.
• W2078482635 cites W2004522121 @default.
• W2078482635 cites W2007136776 @default.
• W2078482635 cites W2008984410 @default.
• W2078482635 cites W2012077729 @default.
• W2078482635 cites W2024490058 @default.
• W2078482635 cites W2030607204 @default.
• W2078482635 cites W2047820200 @default.
• W2078482635 cites W2074576643 @default.
• W2078482635 cites W2081386448 @default.
• W2078482635 cites W2084104947 @default.
• W2078482635 cites W2085682228 @default.
• W2078482635 cites W2107066107 @default.
• W2078482635 cites W2107312924 @default.
• W2078482635 cites W2108054699 @default.
• W2078482635 cites W2111225227 @default.
• W2078482635 cites W2130204211 @default.
• W2078482635 cites W2130253814 @default.
• W2078482635 cites W2138453840 @default.
• W2078482635 cites W2141077451 @default.
• W2078482635 cites W2142017607 @default.
• W2078482635 doi "https://doi.org/10.1073/pnas.0911755107" @default.
• W2078482635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2851859" @default.
• W2078482635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20231432" @default.
• W2078482635 hasPublicationYear "2010" @default.
• W2078482635 type Work @default.
• W2078482635 sameAs 2078482635 @default.
• W2078482635 citedByCount "145" @default.
• W2078482635 countsByYear W20784826352012 @default.
• W2078482635 countsByYear W20784826352013 @default.
• W2078482635 countsByYear W20784826352014 @default.
• W2078482635 countsByYear W20784826352015 @default.
• W2078482635 countsByYear W20784826352016 @default.
• W2078482635 countsByYear W20784826352017 @default.
• W2078482635 countsByYear W20784826352018 @default.
• W2078482635 countsByYear W20784826352019 @default.
• W2078482635 countsByYear W20784826352020 @default.
• W2078482635 countsByYear W20784826352021 @default.
• W2078482635 countsByYear W20784826352022 @default.
• W2078482635 countsByYear W20784826352023 @default.
• W2078482635 crossrefType "journal-article" @default.
• W2078482635 hasAuthorship W2078482635A5001884814 @default.
• W2078482635 hasAuthorship W2078482635A5059554216 @default.
• W2078482635 hasAuthorship W2078482635A5070727803 @default.
• W2078482635 hasAuthorship W2078482635A5074188154 @default.
• W2078482635 hasAuthorship W2078482635A5083297478 @default.
• W2078482635 hasAuthorship W2078482635A5085603605 @default.
• W2078482635 hasAuthorship W2078482635A5087850032 @default.
• W2078482635 hasBestOaLocation W20784826352 @default.
• W2078482635 hasConcept C104317684 @default.
• W2078482635 hasConcept C134018914 @default.
• W2078482635 hasConcept C203014093 @default.
• W2078482635 hasConcept C2776090121 @default.
• W2078482635 hasConcept C2778690821 @default.
• W2078482635 hasConcept C33594762 @default.
• W2078482635 hasConcept C49039625 @default.
• W2078482635 hasConcept C55493867 @default.
• W2078482635 hasConcept C62478195 @default.
• W2078482635 hasConcept C86339819 @default.
• W2078482635 hasConcept C86803240 @default.
• W2078482635 hasConcept C8891405 @default.
• W2078482635 hasConcept C95444343 @default.
• W2078482635 hasConceptScore W2078482635C104317684 @default.
• W2078482635 hasConceptScore W2078482635C134018914 @default.
• W2078482635 hasConceptScore W2078482635C203014093 @default.
• W2078482635 hasConceptScore W2078482635C2776090121 @default.
• W2078482635 hasConceptScore W2078482635C2778690821 @default.
• W2078482635 hasConceptScore W2078482635C33594762 @default.
• W2078482635 hasConceptScore W2078482635C49039625 @default.
• W2078482635 hasConceptScore W2078482635C55493867 @default.
• W2078482635 hasConceptScore W2078482635C62478195 @default.
• W2078482635 hasConceptScore W2078482635C86339819 @default.
• W2078482635 hasConceptScore W2078482635C86803240 @default.
• W2078482635 hasConceptScore W2078482635C8891405 @default.
• W2078482635 hasConceptScore W2078482635C95444343 @default.
• W2078482635 hasIssue "13" @default.
• W2078482635 hasLocation W20784826351 @default.
• W2078482635 hasLocation W20784826352 @default.

• next