FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078483071> ?p ?o ?g. }

• W2078483071 endingPage "1091" @default.
• W2078483071 startingPage "1084" @default.
• W2078483071 abstract "Homocysteine (Hcy) has recently been recognized as an integral component of several disorders. However, the association between hyperhomocysteinemia (HHcy) and pulmonary disease is not well understood. The combination of two-dimensional electrophoresis and tandem mass spectrometry detected and identified proteins that are differentially expressed in human type II alveolar epithelial cells (A549 cells) treated by Hcy. We found that aldose reductase (AR) showed more abundant expression in the cells. Further, Hcy (100-500microM) could induce a time- and dose-dependent upregulation of AR protein levels. Immunohistochemical staining of cross-sections from HHcy mice lungs also revealed increased expression of AR protein. Intracellular levels of reactive oxygen species (ROS) were remarkably elevated in A549 cells treated with Hcy. Pretreatment of A549 cells with catalase and SOD significantly suppressed the Hcy-induced AR expression, which suggests the involvement of ROS in this process. The major signaling pathway mediating the upregulation of AR was demonstrated to be the Ras/Raf/ERK1/2 pathway. In addition, Hcy might reduce surfactant protein B (SP-B) expression in the cells, which could be significantly attenuated by Alrestatin, an AR inhibitor, indicating a damaging role of Hcy-induced AR elevation in the lung. These results show a novel and unanticipated link between HHcy and AR upregulation that may be a risk factor in pulmonary disease of patients with HHcy." @default.
• W2078483071 created "2016-06-24" @default.
• W2078483071 creator A5009875459 @default.
• W2078483071 creator A5014895634 @default.
• W2078483071 creator A5026966223 @default.
• W2078483071 creator A5062607187 @default.
• W2078483071 creator A5067018873 @default.
• W2078483071 creator A5088434627 @default.
• W2078483071 date "2005-12-01" @default.
• W2078483071 modified "2023-09-26" @default.
• W2078483071 title "Upregulation of aldose reductase by homocysteine in type II alveolar epithelial cells" @default.
• W2078483071 cites W1565032730 @default.
• W2078483071 cites W1601924230 @default.
• W2078483071 cites W1817730472 @default.
• W2078483071 cites W1966994165 @default.
• W2078483071 cites W1975357252 @default.
• W2078483071 cites W1990402565 @default.
• W2078483071 cites W2044766431 @default.
• W2078483071 cites W2052588755 @default.
• W2078483071 cites W2057522312 @default.
• W2078483071 cites W2059033005 @default.
• W2078483071 cites W2061407410 @default.
• W2078483071 cites W2062378136 @default.
• W2078483071 cites W2074488178 @default.
• W2078483071 cites W2090552979 @default.
• W2078483071 cites W2092179638 @default.
• W2078483071 cites W2115276193 @default.
• W2078483071 cites W2149154883 @default.
• W2078483071 cites W2159055946 @default.
• W2078483071 cites W2161499436 @default.
• W2078483071 cites W2163411908 @default.
• W2078483071 cites W2164721380 @default.
• W2078483071 cites W2179225990 @default.
• W2078483071 cites W2342150662 @default.
• W2078483071 doi "https://doi.org/10.1016/j.bbrc.2005.09.160" @default.
• W2078483071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16225842" @default.
• W2078483071 hasPublicationYear "2005" @default.
• W2078483071 type Work @default.
• W2078483071 sameAs 2078483071 @default.
• W2078483071 citedByCount "8" @default.
• W2078483071 countsByYear W20784830712012 @default.
• W2078483071 countsByYear W20784830712013 @default.
• W2078483071 countsByYear W20784830712019 @default.
• W2078483071 countsByYear W20784830712021 @default.
• W2078483071 countsByYear W20784830712022 @default.
• W2078483071 crossrefType "journal-article" @default.
• W2078483071 hasAuthorship W2078483071A5009875459 @default.
• W2078483071 hasAuthorship W2078483071A5014895634 @default.
• W2078483071 hasAuthorship W2078483071A5026966223 @default.
• W2078483071 hasAuthorship W2078483071A5062607187 @default.
• W2078483071 hasAuthorship W2078483071A5067018873 @default.
• W2078483071 hasAuthorship W2078483071A5088434627 @default.
• W2078483071 hasConcept C104317684 @default.
• W2078483071 hasConcept C126322002 @default.
• W2078483071 hasConcept C127561419 @default.
• W2078483071 hasConcept C134018914 @default.
• W2078483071 hasConcept C153911025 @default.
• W2078483071 hasConcept C181199279 @default.
• W2078483071 hasConcept C185592680 @default.
• W2078483071 hasConcept C2776439734 @default.
• W2078483071 hasConcept C2776523773 @default.
• W2078483071 hasConcept C2777090595 @default.
• W2078483071 hasConcept C48349386 @default.
• W2078483071 hasConcept C55493867 @default.
• W2078483071 hasConcept C71924100 @default.
• W2078483071 hasConcept C86803240 @default.
• W2078483071 hasConceptScore W2078483071C104317684 @default.
• W2078483071 hasConceptScore W2078483071C126322002 @default.
• W2078483071 hasConceptScore W2078483071C127561419 @default.
• W2078483071 hasConceptScore W2078483071C134018914 @default.
• W2078483071 hasConceptScore W2078483071C153911025 @default.
• W2078483071 hasConceptScore W2078483071C181199279 @default.
• W2078483071 hasConceptScore W2078483071C185592680 @default.
• W2078483071 hasConceptScore W2078483071C2776439734 @default.
• W2078483071 hasConceptScore W2078483071C2776523773 @default.
• W2078483071 hasConceptScore W2078483071C2777090595 @default.
• W2078483071 hasConceptScore W2078483071C48349386 @default.
• W2078483071 hasConceptScore W2078483071C55493867 @default.
• W2078483071 hasConceptScore W2078483071C71924100 @default.
• W2078483071 hasConceptScore W2078483071C86803240 @default.
• W2078483071 hasIssue "4" @default.
• W2078483071 hasLocation W20784830711 @default.
• W2078483071 hasLocation W20784830712 @default.
• W2078483071 hasOpenAccess W2078483071 @default.
• W2078483071 hasPrimaryLocation W20784830711 @default.
• W2078483071 hasRelatedWork W2020449916 @default.
• W2078483071 hasRelatedWork W2025703417 @default.
• W2078483071 hasRelatedWork W2107729314 @default.
• W2078483071 hasRelatedWork W2114945237 @default.
• W2078483071 hasRelatedWork W2143676904 @default.
• W2078483071 hasRelatedWork W2157270415 @default.
• W2078483071 hasRelatedWork W2409608972 @default.
• W2078483071 hasRelatedWork W2625556364 @default.
• W2078483071 hasRelatedWork W2758750505 @default.
• W2078483071 hasRelatedWork W4220896095 @default.
• W2078483071 hasVolume "337" @default.
• W2078483071 isParatext "false" @default.
• W2078483071 isRetracted "false" @default.

• next