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- W2078485402 abstract "Cognitive dysfunction in schizophrenia is associated with a lower density of dendritic spines on deep layer 3 pyramidal cells in the dorsolateral prefrontal cortex (DLPFC). These alterations appear to reflect dysregulation of the actin cytoskeleton required for spine formation and maintenance. Consistent with this idea, altered expression of genes in the cell division cycle 42 (CDC42)-CDC42 effector protein (CDC42EP) signaling pathway, a key organizer of the actin cytoskeleton, was previously reported in DLPFC gray matter from subjects with schizophrenia. We examined the integrity of the CDC42-p21-activated serine/threonine protein kinases (PAK)-LIM domain-containing serine/threonine protein kinases (LIMK) signaling pathway in schizophrenia in a layer-specific and cell type-specific fashion in DLPFC deep layer 3.Using laser microdissection, samples of DLPFC deep layer 3 were collected from 56 matched pairs of subjects with schizophrenia and comparison subjects, and levels of CDC42-PAK-LIMK pathway messenger RNAs were measured by quantitative polymerase chain reaction. These same transcripts also were quantified by microarray in samples of individually microdissected deep layer 3 pyramidal cells from a subset of the same subjects and from monkeys exposed to antipsychotics.Relative to comparison subjects, CDC42EP4, LIMK1, LIMK2, ARHGDIA, and PAK3 messenger RNA levels were significantly upregulated in subjects with schizophrenia in laminar and cellular samples. In contrast, CDC42 and PAK1 messenger RNA levels were significantly downregulated specifically in deep layer 3 pyramidal cells. These differences were not attributable to psychotropic medications or other comorbid factors.Findings from the present and prior studies converge on synergistic alterations in CDC42 signaling pathway that could destabilize actin dynamics and produce spine deficits preferentially in deep layer 3 pyramidal cells in schizophrenia." @default.
- W2078485402 created "2016-06-24" @default.
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- W2078485402 date "2015-12-01" @default.
- W2078485402 modified "2023-10-18" @default.
- W2078485402 title "Altered Expression of CDC42 Signaling Pathway Components in Cortical Layer 3 Pyramidal Cells in Schizophrenia" @default.
- W2078485402 cites W1483413992 @default.
- W2078485402 cites W1490646520 @default.
- W2078485402 cites W151176851 @default.
- W2078485402 cites W1567217875 @default.
- W2078485402 cites W1915770046 @default.
- W2078485402 cites W1927958250 @default.
- W2078485402 cites W1939600354 @default.
- W2078485402 cites W1969693529 @default.
- W2078485402 cites W1974232070 @default.
- W2078485402 cites W1981225314 @default.
- W2078485402 cites W1989278867 @default.
- W2078485402 cites W1989629219 @default.
- W2078485402 cites W1989747504 @default.
- W2078485402 cites W1991503782 @default.
- W2078485402 cites W1994844322 @default.
- W2078485402 cites W1995362640 @default.
- W2078485402 cites W1997950587 @default.
- W2078485402 cites W1998046189 @default.
- W2078485402 cites W1999668406 @default.
- W2078485402 cites W2000526380 @default.
- W2078485402 cites W2004451728 @default.
- W2078485402 cites W2008458159 @default.
- W2078485402 cites W2008682443 @default.
- W2078485402 cites W2010735491 @default.
- W2078485402 cites W2011107835 @default.
- W2078485402 cites W2011756230 @default.
- W2078485402 cites W2013012792 @default.
- W2078485402 cites W2014779394 @default.
- W2078485402 cites W2021703037 @default.
- W2078485402 cites W2023962370 @default.
- W2078485402 cites W2024142657 @default.
- W2078485402 cites W2028554055 @default.
- W2078485402 cites W2030609555 @default.
- W2078485402 cites W2031684016 @default.
- W2078485402 cites W2035009272 @default.
- W2078485402 cites W2040567131 @default.
- W2078485402 cites W2048571739 @default.
- W2078485402 cites W2052882602 @default.
- W2078485402 cites W2054585593 @default.
- W2078485402 cites W2059890547 @default.
- W2078485402 cites W2061895982 @default.
- W2078485402 cites W2062287817 @default.
- W2078485402 cites W2068923943 @default.
- W2078485402 cites W2070938360 @default.
- W2078485402 cites W2083809363 @default.
- W2078485402 cites W2085848150 @default.
- W2078485402 cites W2087809804 @default.
- W2078485402 cites W2088863821 @default.
- W2078485402 cites W2089742079 @default.
- W2078485402 cites W2092348167 @default.
- W2078485402 cites W2093279875 @default.
- W2078485402 cites W2097088842 @default.
- W2078485402 cites W2098391962 @default.
- W2078485402 cites W2099125139 @default.
- W2078485402 cites W2099192887 @default.
- W2078485402 cites W2103407592 @default.
- W2078485402 cites W2103592460 @default.
- W2078485402 cites W2110373490 @default.
- W2078485402 cites W2113054165 @default.
- W2078485402 cites W2114129553 @default.
- W2078485402 cites W2121980152 @default.
- W2078485402 cites W2121999864 @default.
- W2078485402 cites W2126843605 @default.
- W2078485402 cites W2129208121 @default.
- W2078485402 cites W2135282772 @default.
- W2078485402 cites W2136337975 @default.
- W2078485402 cites W2136929119 @default.
- W2078485402 cites W2137313711 @default.
- W2078485402 cites W2139503583 @default.
- W2078485402 cites W2146264275 @default.
- W2078485402 cites W2158137297 @default.
- W2078485402 cites W2159400463 @default.
- W2078485402 cites W2160964316 @default.
- W2078485402 cites W2162916231 @default.
- W2078485402 cites W2165775739 @default.
- W2078485402 cites W2170696995 @default.
- W2078485402 cites W2400688595 @default.
- W2078485402 doi "https://doi.org/10.1016/j.biopsych.2015.03.030" @default.
- W2078485402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4600637" @default.
- W2078485402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25981171" @default.
- W2078485402 hasPublicationYear "2015" @default.
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