Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078485810> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2078485810 endingPage "1185" @default.
- W2078485810 startingPage "1183" @default.
- W2078485810 abstract "Advancing our knowledge on the toxicology of combined exposures to chemicals and implementation of this knowledge in guidelines for health risk assessment of such combined exposures are necessities dictated by the simple fact that humans are continuously exposed to a multitude of chemicals. A prerequisite for successful research and fruitful discussions on the toxicology of combined exposures (mixtures of chemicals) is the use of defined terminology implemented by an authoritative international body such as, for example, the International Union of Pure and Applied Chemistry (IUPAC) Toxicology Committee. The extreme complexity of mixture toxicology calls for new research methodologies to study interactive effects, taking into account limited resources. Of these methodologies, statistical designs and mathematical modelling of toxicokinetics and toxicodynamics seem to be most promising. Emphasis should be placed on low-dose modelling and experimental validation. The scientifically sound so-called bottom-up approach should be supplemented with more pragmatic approaches, focusing on selection of the most hazardous chemicals in a mixture and careful consideration of the mode of action and possible interactive effects of these chemicals. Pragmatic approaches may be of particular importance to study and evaluate complex mixtures; after identification of the 'top ten' (most risky) chemicals in the mixture they can be examined and evaluated as a defined (simple) chemical mixture. In setting exposure limits for individual chemicals, the use of an additional safety factor to compensate for potential increased risk due to simultaneous exposure to other chemicals, has no clear scientific justification. The use of such an additional factor is a political rather than a scientific choice." @default.
- W2078485810 created "2016-06-24" @default.
- W2078485810 creator A5002205309 @default.
- W2078485810 creator A5005536202 @default.
- W2078485810 creator A5016370440 @default.
- W2078485810 creator A5052487911 @default.
- W2078485810 creator A5054795395 @default.
- W2078485810 date "1996-11-01" @default.
- W2078485810 modified "2023-10-16" @default.
- W2078485810 title "Experimental designs and risk assessment in combination toxicology: Panel discussion" @default.
- W2078485810 doi "https://doi.org/10.1016/s0278-6915(97)00097-5" @default.
- W2078485810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9119339" @default.
- W2078485810 hasPublicationYear "1996" @default.
- W2078485810 type Work @default.
- W2078485810 sameAs 2078485810 @default.
- W2078485810 citedByCount "25" @default.
- W2078485810 countsByYear W20784858102012 @default.
- W2078485810 countsByYear W20784858102013 @default.
- W2078485810 countsByYear W20784858102018 @default.
- W2078485810 countsByYear W20784858102020 @default.
- W2078485810 countsByYear W20784858102021 @default.
- W2078485810 countsByYear W20784858102023 @default.
- W2078485810 crossrefType "journal-article" @default.
- W2078485810 hasAuthorship W2078485810A5002205309 @default.
- W2078485810 hasAuthorship W2078485810A5005536202 @default.
- W2078485810 hasAuthorship W2078485810A5016370440 @default.
- W2078485810 hasAuthorship W2078485810A5052487911 @default.
- W2078485810 hasAuthorship W2078485810A5054795395 @default.
- W2078485810 hasConcept C112705442 @default.
- W2078485810 hasConcept C112930515 @default.
- W2078485810 hasConcept C116834253 @default.
- W2078485810 hasConcept C12174686 @default.
- W2078485810 hasConcept C127413603 @default.
- W2078485810 hasConcept C138885662 @default.
- W2078485810 hasConcept C183696295 @default.
- W2078485810 hasConcept C195289149 @default.
- W2078485810 hasConcept C19749203 @default.
- W2078485810 hasConcept C33070731 @default.
- W2078485810 hasConcept C38652104 @default.
- W2078485810 hasConcept C41008148 @default.
- W2078485810 hasConcept C41895202 @default.
- W2078485810 hasConcept C539667460 @default.
- W2078485810 hasConcept C547195049 @default.
- W2078485810 hasConcept C59822182 @default.
- W2078485810 hasConcept C60644358 @default.
- W2078485810 hasConcept C71924100 @default.
- W2078485810 hasConcept C86803240 @default.
- W2078485810 hasConceptScore W2078485810C112705442 @default.
- W2078485810 hasConceptScore W2078485810C112930515 @default.
- W2078485810 hasConceptScore W2078485810C116834253 @default.
- W2078485810 hasConceptScore W2078485810C12174686 @default.
- W2078485810 hasConceptScore W2078485810C127413603 @default.
- W2078485810 hasConceptScore W2078485810C138885662 @default.
- W2078485810 hasConceptScore W2078485810C183696295 @default.
- W2078485810 hasConceptScore W2078485810C195289149 @default.
- W2078485810 hasConceptScore W2078485810C19749203 @default.
- W2078485810 hasConceptScore W2078485810C33070731 @default.
- W2078485810 hasConceptScore W2078485810C38652104 @default.
- W2078485810 hasConceptScore W2078485810C41008148 @default.
- W2078485810 hasConceptScore W2078485810C41895202 @default.
- W2078485810 hasConceptScore W2078485810C539667460 @default.
- W2078485810 hasConceptScore W2078485810C547195049 @default.
- W2078485810 hasConceptScore W2078485810C59822182 @default.
- W2078485810 hasConceptScore W2078485810C60644358 @default.
- W2078485810 hasConceptScore W2078485810C71924100 @default.
- W2078485810 hasConceptScore W2078485810C86803240 @default.
- W2078485810 hasIssue "11-12" @default.
- W2078485810 hasLocation W20784858101 @default.
- W2078485810 hasLocation W20784858102 @default.
- W2078485810 hasOpenAccess W2078485810 @default.
- W2078485810 hasPrimaryLocation W20784858101 @default.
- W2078485810 hasRelatedWork W10590296 @default.
- W2078485810 hasRelatedWork W1249098568 @default.
- W2078485810 hasRelatedWork W1579692432 @default.
- W2078485810 hasRelatedWork W2082454110 @default.
- W2078485810 hasRelatedWork W2133414026 @default.
- W2078485810 hasRelatedWork W2165127149 @default.
- W2078485810 hasRelatedWork W3021733891 @default.
- W2078485810 hasRelatedWork W3103154611 @default.
- W2078485810 hasRelatedWork W4226538164 @default.
- W2078485810 hasRelatedWork W4248084236 @default.
- W2078485810 hasVolume "34" @default.
- W2078485810 isParatext "false" @default.
- W2078485810 isRetracted "false" @default.
- W2078485810 magId "2078485810" @default.
- W2078485810 workType "article" @default.