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- W2078486308 abstract "We assessed the effect of diabetes on antinociception produced by intracerebroventricular injection of δ-opioid receptor agonists [D-Pen2,5]enkephalin (DPDPE) and [D-Ala2]deltorphin II. The antinociceptive effect of DPDPE (10 nmol), administered i.c.v., was significantly greater in diabetic mice than in non-diabetic mice. The antinociceptive effect of i.c.v. DPDPE was significantly reduced in both diabetic and non-diabetic mice following pretreatment with 7-benzylidenenaltrexone (BNTX), a selective δ1-opioid receptor antagonist, but not with naltriben (NTB), a selective δ2- opioid receptor antagonist. There were no significant differences in the anticiceptive effect of [D-Ala2]deltorphin II (3 nmol, i.c.v.) in diabetic and non-diabetic mice. Furthermore, the antinociceptive effect of i.c.v. [D-Ala2]deltorphin II was significantly reduced in both diabetic and non-diabetic mice following pretreatment with NTB, but not with BNTX. In conclusion, mice with diabetes are selectively hyper-responsive to supraspinal δ1-opioid receptor-mediated antinociception, but are normally responsive to activation of δ2-opiod receptors." @default.
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- W2078486308 date "1994-01-01" @default.
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- W2078486308 title "Streptozotocin-induced diabetes selectively enhances antinociception mediated by δ1-but not δ2-opioid receptors" @default.
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- W2078486308 doi "https://doi.org/10.1016/0024-3205(94)90062-0" @default.
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