FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078487578> ?p ?o ?g. }

• W2078487578 endingPage "1087" @default.
• W2078487578 startingPage "1080" @default.
• W2078487578 abstract "Several studies in different populations have suggested that nighttime blood pressure (BP) is a stronger predictor of cardiovascular events than daytime BP. Consequently, treatment strategies to target nighttime BP have come into focus. The aim of the present study was to investigate the effect of change of administration time of antihypertensive drugs. We included 41 patients with type 2 diabetes mellitus and nocturnal hypertension (nighttime systolic BP >120 mm Hg) in an open-label, crossover study. Patients were randomized to 8 weeks of either morning or bedtime administration of all of the individual’s once-daily antihypertensive drugs, followed by 8 weeks of switched dosing regimen. Bedtime administration of antihypertensive drugs resulted in a significant reduction in nighttime (7.5 mm Hg; P <0.001) and 24-hour (3.1 mm Hg; P =0.014) systolic BP, with a nonsignificant reduction in daytime (1.3 mm Hg; P =0.336) systolic BP. We did not find morning BP surge to be different between dosing regimens. Levels of C-reactive protein were significantly lower with bedtime administration, which may indicate an effect on low-grade inflammation. We found no difference in urinary albumin excretion, regardless of albuminuria status. Urinary sodium/creatinine was significantly increased and urinary osmolality significantly reduced with bedtime administration, which can be interpreted as increased nocturnal natriuresis. In patients with type 2 diabetes mellitus and nocturnal hypertension, administration of once-daily antihypertensive drugs at bedtime may be favorable. The increased nocturnal natriuresis may reflect increased effect of bedtime-administered thiazides and renin–angiotensin system inhibitors, suggesting a potential mechanism of the observed effects on BP with chronotherapeutic intervention." @default.
• W2078487578 created "2016-06-24" @default.
• W2078487578 creator A5008427796 @default.
• W2078487578 creator A5020030553 @default.
• W2078487578 creator A5022851450 @default.
• W2078487578 creator A5042492779 @default.
• W2078487578 creator A5051249313 @default.
• W2078487578 creator A5066807883 @default.
• W2078487578 creator A5077448551 @default.
• W2078487578 date "2014-11-01" @default.
• W2078487578 modified "2023-10-11" @default.
• W2078487578 title "Targeting Nocturnal Hypertension in Type 2 Diabetes Mellitus" @default.
• W2078487578 cites W1570583414 @default.
• W2078487578 cites W1812416290 @default.
• W2078487578 cites W1970556806 @default.
• W2078487578 cites W1976940745 @default.
• W2078487578 cites W1977329117 @default.
• W2078487578 cites W1979361829 @default.
• W2078487578 cites W1987114939 @default.
• W2078487578 cites W1992145371 @default.
• W2078487578 cites W1992351796 @default.
• W2078487578 cites W1994523355 @default.
• W2078487578 cites W2004110182 @default.
• W2078487578 cites W2010912810 @default.
• W2078487578 cites W2015127639 @default.
• W2078487578 cites W2056808529 @default.
• W2078487578 cites W2065232710 @default.
• W2078487578 cites W2078469116 @default.
• W2078487578 cites W2081535973 @default.
• W2078487578 cites W2094513056 @default.
• W2078487578 cites W2098672359 @default.
• W2078487578 cites W2098944132 @default.
• W2078487578 cites W2099301718 @default.
• W2078487578 cites W2103015566 @default.
• W2078487578 cites W2128278910 @default.
• W2078487578 cites W2133295920 @default.
• W2078487578 cites W2141454310 @default.
• W2078487578 cites W2142727265 @default.
• W2078487578 cites W2146282879 @default.
• W2078487578 cites W2147663252 @default.
• W2078487578 cites W2148066505 @default.
• W2078487578 cites W2148278067 @default.
• W2078487578 cites W2148644774 @default.
• W2078487578 cites W2153034914 @default.
• W2078487578 cites W2154023819 @default.
• W2078487578 cites W2164802857 @default.
• W2078487578 cites W2167557672 @default.
• W2078487578 cites W2167915551 @default.
• W2078487578 cites W2554729258 @default.
• W2078487578 doi "https://doi.org/10.1161/hypertensionaha.114.03958" @default.
• W2078487578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25259747" @default.
• W2078487578 hasPublicationYear "2014" @default.
• W2078487578 type Work @default.
• W2078487578 sameAs 2078487578 @default.
• W2078487578 citedByCount "41" @default.
• W2078487578 countsByYear W20784875782015 @default.
• W2078487578 countsByYear W20784875782016 @default.
• W2078487578 countsByYear W20784875782017 @default.
• W2078487578 countsByYear W20784875782018 @default.
• W2078487578 countsByYear W20784875782019 @default.
• W2078487578 countsByYear W20784875782020 @default.
• W2078487578 countsByYear W20784875782021 @default.
• W2078487578 countsByYear W20784875782022 @default.
• W2078487578 countsByYear W20784875782023 @default.
• W2078487578 crossrefType "journal-article" @default.
• W2078487578 hasAuthorship W2078487578A5008427796 @default.
• W2078487578 hasAuthorship W2078487578A5020030553 @default.
• W2078487578 hasAuthorship W2078487578A5022851450 @default.
• W2078487578 hasAuthorship W2078487578A5042492779 @default.
• W2078487578 hasAuthorship W2078487578A5051249313 @default.
• W2078487578 hasAuthorship W2078487578A5066807883 @default.
• W2078487578 hasAuthorship W2078487578A5077448551 @default.
• W2078487578 hasConcept C126322002 @default.
• W2078487578 hasConcept C134018914 @default.
• W2078487578 hasConcept C174459258 @default.
• W2078487578 hasConcept C19720800 @default.
• W2078487578 hasConcept C2776174234 @default.
• W2078487578 hasConcept C2778537899 @default.
• W2078487578 hasConcept C555293320 @default.
• W2078487578 hasConcept C71924100 @default.
• W2078487578 hasConcept C84393581 @default.
• W2078487578 hasConceptScore W2078487578C126322002 @default.
• W2078487578 hasConceptScore W2078487578C134018914 @default.
• W2078487578 hasConceptScore W2078487578C174459258 @default.
• W2078487578 hasConceptScore W2078487578C19720800 @default.
• W2078487578 hasConceptScore W2078487578C2776174234 @default.
• W2078487578 hasConceptScore W2078487578C2778537899 @default.
• W2078487578 hasConceptScore W2078487578C555293320 @default.
• W2078487578 hasConceptScore W2078487578C71924100 @default.
• W2078487578 hasConceptScore W2078487578C84393581 @default.
• W2078487578 hasIssue "5" @default.
• W2078487578 hasLocation W20784875781 @default.
• W2078487578 hasLocation W20784875782 @default.
• W2078487578 hasOpenAccess W2078487578 @default.
• W2078487578 hasPrimaryLocation W20784875781 @default.
• W2078487578 hasRelatedWork W1606501554 @default.
• W2078487578 hasRelatedWork W1646849474 @default.
• W2078487578 hasRelatedWork W1799770855 @default.

• next