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- W2078488711 abstract "Ethanol was applied directly to cultures of mouse cerebellum and cerebral neocortex while spontaneous electrical activity was monitored in the former and stimulus-elicited responses were monitored in the latter. Ethanol characteristically demonstrated an initial excitatory effect on cerebellar cultures, manifested by an increase in spontaneous discharge rate, followed by a depression of spontaneous activity. Only depressant effects were noted in ethanol-treated cerebral neocortex cultures. In both instances, removal of ethanol by washing with normal medium resulted in a return to baseline electrical activity. The rapid reversibility of the depressant effects was thought to favor a membrane-altering mechanism which impairs ionic exchange. Light and electron microscopic studies of cerebellar cultures treated with 0.21 to 1.55 g ethanol/100 ml medium for 6 to 15 days demonstrated only nonspecific changes, i.e., an increase in lysosomes and autophagic vacuoles, particularly in astrocytes. Both electrophysiological and morphological studies revealed that the effects of ethanol in vitro were generally manifested at concentrations well above levels producing effects in vivo." @default.
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- W2078488711 date "1977-05-01" @default.
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- W2078488711 title "Direct effects of ethanol on central nervous system cultures: An electrophysiological and morphological study" @default.
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- W2078488711 doi "https://doi.org/10.1016/0014-4886(77)90009-7" @default.
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