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- W2078488755 abstract "Summary 1. The effect of angiotensin‐converting enzyme inhibitors (ACEI) enalapril, lisinopril and ramipril was studied on fructose‐induced hypertensive and hyperinsulinaemic rats. 2. 60 Sprague‐Dawley rats were fed a fructose‐enriched diet for 5 weeks, which produced hyperinsulinaemia, hypertri‐glyceridaemia and hypertension. Beginning with week 3 of the diet, lisinopril (10 and 20 mg per kg per day), ramipril (5 and 10 mg/kg per day) and enalapril (20 mg/kg per day) were given daily in drinking water for 2 weeks to 10 rats in each drug group. Ten rats fed only the fructose‐enriched diet served as control. 3. Systolic blood pressure was measured weekly by the indirect tail‐cuff method. Plasma insulin level was determined using RIA. 4. Data indicate that ACEI improve insulin resistance induced by high‐fructose intake in rats; that despite their equal hypotensive effect, ACEI differ in their ability to improve insulin resistance; and that improvement of insulin resistance by ACEI is dose‐dependent." @default.
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- W2078488755 date "1995-11-01" @default.
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- W2078488755 title "EFFECT OF ANGIOTENSIN-CONVERTING ENZYME INHIBITORS ON FRUCTOSE INDUCED HYPERTENSION AND HYPERINSULINAEMIA IN RATS" @default.
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- W2078488755 doi "https://doi.org/10.1111/j.1440-1681.1995.tb02949.x" @default.
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