Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078493306> ?p ?o ?g. }
- W2078493306 endingPage "83" @default.
- W2078493306 startingPage "76" @default.
- W2078493306 abstract "Previously, we reported that a novel secretory protein, pancreatic adenocarcinoma up-regulated factor (PAUF), which is highly expressed in pancreatic cancer and mediates the growth and metastasis of pancreatic cancer cells. In this study, we generated and characterized a 2′-fluoropyrimidine modified RNA aptamer (P12FR2) directed against human PAUF. P12FR2 binds specifically to human PAUF with an estimated apparent KD of 77 nM. P12FR2 aptamer inhibits PAUF-induced migration of PANC-1, human pancreatic cancer cells, in a wound healing assay. Moreover, intraperitoneal injection of P12FR2 decreased tumor growth by about 60% in an in vivo xenograft model with CFPAC-1 pancreatic cancer cells, without causing a loss of weight in the treated mice. Taken together, we propose here that PAUF-specific RNA aptamer, P12FR2, has the potential to be effective in the therapy of human pancreatic cancer." @default.
- W2078493306 created "2016-06-24" @default.
- W2078493306 creator A5000968992 @default.
- W2078493306 creator A5004423233 @default.
- W2078493306 creator A5005087638 @default.
- W2078493306 creator A5008807123 @default.
- W2078493306 creator A5012175176 @default.
- W2078493306 creator A5017138986 @default.
- W2078493306 creator A5020834497 @default.
- W2078493306 creator A5026973631 @default.
- W2078493306 creator A5038480858 @default.
- W2078493306 creator A5052838486 @default.
- W2078493306 creator A5072979269 @default.
- W2078493306 creator A5076552466 @default.
- W2078493306 creator A5086479486 @default.
- W2078493306 date "2011-12-01" @default.
- W2078493306 modified "2023-09-29" @default.
- W2078493306 title "An RNA aptamer that specifically binds pancreatic adenocarcinoma up-regulated factor inhibits migration and growth of pancreatic cancer cells" @default.
- W2078493306 cites W1802218256 @default.
- W2078493306 cites W1931508686 @default.
- W2078493306 cites W1967825083 @default.
- W2078493306 cites W1970773045 @default.
- W2078493306 cites W1990952171 @default.
- W2078493306 cites W1990993077 @default.
- W2078493306 cites W2003153334 @default.
- W2078493306 cites W2009086741 @default.
- W2078493306 cites W2010118863 @default.
- W2078493306 cites W2011102827 @default.
- W2078493306 cites W2022159208 @default.
- W2078493306 cites W2031075581 @default.
- W2078493306 cites W2043367201 @default.
- W2078493306 cites W2054735424 @default.
- W2078493306 cites W2056285082 @default.
- W2078493306 cites W2079321730 @default.
- W2078493306 cites W2104525153 @default.
- W2078493306 cites W2107565528 @default.
- W2078493306 cites W2122992861 @default.
- W2078493306 cites W2128366005 @default.
- W2078493306 cites W2131286114 @default.
- W2078493306 cites W2137057261 @default.
- W2078493306 cites W2144402866 @default.
- W2078493306 cites W2153335790 @default.
- W2078493306 cites W2158134441 @default.
- W2078493306 cites W2158734599 @default.
- W2078493306 cites W2161769699 @default.
- W2078493306 cites W2164529446 @default.
- W2078493306 cites W2290264682 @default.
- W2078493306 cites W4243884342 @default.
- W2078493306 doi "https://doi.org/10.1016/j.canlet.2011.08.027" @default.
- W2078493306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21963224" @default.
- W2078493306 hasPublicationYear "2011" @default.
- W2078493306 type Work @default.
- W2078493306 sameAs 2078493306 @default.
- W2078493306 citedByCount "36" @default.
- W2078493306 countsByYear W20784933062012 @default.
- W2078493306 countsByYear W20784933062013 @default.
- W2078493306 countsByYear W20784933062014 @default.
- W2078493306 countsByYear W20784933062015 @default.
- W2078493306 countsByYear W20784933062016 @default.
- W2078493306 countsByYear W20784933062017 @default.
- W2078493306 countsByYear W20784933062018 @default.
- W2078493306 countsByYear W20784933062019 @default.
- W2078493306 countsByYear W20784933062020 @default.
- W2078493306 countsByYear W20784933062021 @default.
- W2078493306 countsByYear W20784933062022 @default.
- W2078493306 countsByYear W20784933062023 @default.
- W2078493306 crossrefType "journal-article" @default.
- W2078493306 hasAuthorship W2078493306A5000968992 @default.
- W2078493306 hasAuthorship W2078493306A5004423233 @default.
- W2078493306 hasAuthorship W2078493306A5005087638 @default.
- W2078493306 hasAuthorship W2078493306A5008807123 @default.
- W2078493306 hasAuthorship W2078493306A5012175176 @default.
- W2078493306 hasAuthorship W2078493306A5017138986 @default.
- W2078493306 hasAuthorship W2078493306A5020834497 @default.
- W2078493306 hasAuthorship W2078493306A5026973631 @default.
- W2078493306 hasAuthorship W2078493306A5038480858 @default.
- W2078493306 hasAuthorship W2078493306A5052838486 @default.
- W2078493306 hasAuthorship W2078493306A5072979269 @default.
- W2078493306 hasAuthorship W2078493306A5076552466 @default.
- W2078493306 hasAuthorship W2078493306A5086479486 @default.
- W2078493306 hasConcept C104317684 @default.
- W2078493306 hasConcept C121608353 @default.
- W2078493306 hasConcept C126322002 @default.
- W2078493306 hasConcept C128972844 @default.
- W2078493306 hasConcept C150903083 @default.
- W2078493306 hasConcept C153911025 @default.
- W2078493306 hasConcept C185592680 @default.
- W2078493306 hasConcept C207001950 @default.
- W2078493306 hasConcept C22615655 @default.
- W2078493306 hasConcept C2779013556 @default.
- W2078493306 hasConcept C2780210213 @default.
- W2078493306 hasConcept C2781182431 @default.
- W2078493306 hasConcept C502942594 @default.
- W2078493306 hasConcept C55493867 @default.
- W2078493306 hasConcept C67705224 @default.
- W2078493306 hasConcept C71924100 @default.
- W2078493306 hasConcept C86803240 @default.
- W2078493306 hasConcept C96232424 @default.