Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078494465> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2078494465 abstract "Nuclear factor-κB (NFκB) designates a family of transcription factors that has been shown to modulate antiviral, inflammatory and immune responses and promote tumorigenesis. Activation of NFκB is dependent on IKKβ, a component of the IκB kinase (IKK) complex which promotes degradation of IκB inhibitory proteins and allows nuclear translocation of NFκB. Little is known about the role of NFκB signalling in the ovary. We created a gonadal specific IKKβ conditional knockout mouse to explore NFκB action in the ovary. A transgenic mouse line containing floxed IKKβ alleles (M Karin, UCSD) was crossed with a transgenic mouse line expressing cre-recombinase under the control of the anti-Müllerian hormone receptor (AMHR) promoter (M Matzuk, BCM). Female mice arising from this breeding regime will not express IKKβ in granulosa cells and cannot activate NFκB signalling. Ovaries and serum were collected from mice at 7 and 15 weeks of age. Histological analyses were undertaken and the gonadotrophic hormones, follicle stimulating hormone (FSH) and luteinising hormone (LH) were measured. The ovaries of 7 week old IKKβ null mice contained follicles of all developmental stages although corpora lutea were absent indicating that these mice were infertile. Some follicle subtypes may be under-represented and apoptosis may be enhanced; these studies are ongoing. Serum FSH and LH levels were elevated compared to littermate controls. By 15 weeks of age corpora lutea were present. The fertility of the IKKβ conditional knockout is currently being assessed. In summary, IKKβ conditional knockout mice exhibit a reproductive phenotype which includes delayed ovulation. These results validate the hypothesis that ovulation is an inflammatory-like response. This model will be a valuable tool for reproductive research; the subtlety of the phenotype allowing us to tease out the underlying mechanisms and role of NFκB signalling in ovarian function." @default.
- W2078494465 created "2016-06-24" @default.
- W2078494465 creator A5011944041 @default.
- W2078494465 creator A5046419066 @default.
- W2078494465 creator A5050511158 @default.
- W2078494465 date "2010-01-01" @default.
- W2078494465 modified "2023-09-25" @default.
- W2078494465 title "129. OVARIAN PHENOTYPE OF THE IKK CONDITIONAL KNOCKOUT MOUSE" @default.
- W2078494465 doi "https://doi.org/10.1071/srb10abs129" @default.
- W2078494465 hasPublicationYear "2010" @default.
- W2078494465 type Work @default.
- W2078494465 sameAs 2078494465 @default.
- W2078494465 citedByCount "0" @default.
- W2078494465 crossrefType "journal-article" @default.
- W2078494465 hasAuthorship W2078494465A5011944041 @default.
- W2078494465 hasAuthorship W2078494465A5046419066 @default.
- W2078494465 hasAuthorship W2078494465A5050511158 @default.
- W2078494465 hasConcept C100175707 @default.
- W2078494465 hasConcept C102230213 @default.
- W2078494465 hasConcept C102570824 @default.
- W2078494465 hasConcept C104317684 @default.
- W2078494465 hasConcept C125929170 @default.
- W2078494465 hasConcept C126322002 @default.
- W2078494465 hasConcept C127716648 @default.
- W2078494465 hasConcept C134018914 @default.
- W2078494465 hasConcept C141035611 @default.
- W2078494465 hasConcept C164659718 @default.
- W2078494465 hasConcept C170493617 @default.
- W2078494465 hasConcept C182704531 @default.
- W2078494465 hasConcept C2777730290 @default.
- W2078494465 hasConcept C2778324911 @default.
- W2078494465 hasConcept C54355233 @default.
- W2078494465 hasConcept C62478195 @default.
- W2078494465 hasConcept C71924100 @default.
- W2078494465 hasConcept C86803240 @default.
- W2078494465 hasConcept C95444343 @default.
- W2078494465 hasConceptScore W2078494465C100175707 @default.
- W2078494465 hasConceptScore W2078494465C102230213 @default.
- W2078494465 hasConceptScore W2078494465C102570824 @default.
- W2078494465 hasConceptScore W2078494465C104317684 @default.
- W2078494465 hasConceptScore W2078494465C125929170 @default.
- W2078494465 hasConceptScore W2078494465C126322002 @default.
- W2078494465 hasConceptScore W2078494465C127716648 @default.
- W2078494465 hasConceptScore W2078494465C134018914 @default.
- W2078494465 hasConceptScore W2078494465C141035611 @default.
- W2078494465 hasConceptScore W2078494465C164659718 @default.
- W2078494465 hasConceptScore W2078494465C170493617 @default.
- W2078494465 hasConceptScore W2078494465C182704531 @default.
- W2078494465 hasConceptScore W2078494465C2777730290 @default.
- W2078494465 hasConceptScore W2078494465C2778324911 @default.
- W2078494465 hasConceptScore W2078494465C54355233 @default.
- W2078494465 hasConceptScore W2078494465C62478195 @default.
- W2078494465 hasConceptScore W2078494465C71924100 @default.
- W2078494465 hasConceptScore W2078494465C86803240 @default.
- W2078494465 hasConceptScore W2078494465C95444343 @default.
- W2078494465 hasLocation W20784944651 @default.
- W2078494465 hasOpenAccess W2078494465 @default.
- W2078494465 hasPrimaryLocation W20784944651 @default.
- W2078494465 hasRelatedWork W1593890756 @default.
- W2078494465 hasRelatedWork W1971795827 @default.
- W2078494465 hasRelatedWork W1976657370 @default.
- W2078494465 hasRelatedWork W1985131166 @default.
- W2078494465 hasRelatedWork W1985715614 @default.
- W2078494465 hasRelatedWork W1987678808 @default.
- W2078494465 hasRelatedWork W2014358386 @default.
- W2078494465 hasRelatedWork W2015094476 @default.
- W2078494465 hasRelatedWork W2016113290 @default.
- W2078494465 hasRelatedWork W2031663826 @default.
- W2078494465 hasRelatedWork W2067615785 @default.
- W2078494465 hasRelatedWork W2083266214 @default.
- W2078494465 hasRelatedWork W2087140378 @default.
- W2078494465 hasRelatedWork W2098716855 @default.
- W2078494465 hasRelatedWork W2110698122 @default.
- W2078494465 hasRelatedWork W2123455822 @default.
- W2078494465 hasRelatedWork W2133196685 @default.
- W2078494465 hasRelatedWork W2164198570 @default.
- W2078494465 hasRelatedWork W2170508619 @default.
- W2078494465 hasRelatedWork W2171539702 @default.
- W2078494465 isParatext "false" @default.
- W2078494465 isRetracted "false" @default.
- W2078494465 magId "2078494465" @default.
- W2078494465 workType "article" @default.