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• W2078498555 startingPage "1045" @default.
• W2078498555 abstract "Previous studies in a fetal erythroid cell line demonstrated that the transcription factor, Krüppel-like factor 11 (KLF11), could specifically induce transcription from a gamma-globin gene promoter, and that this induction was mediated through a specific canonical CACCC cis-DNA binding motif. We report here that ectopic expression of KLF11 can also induce fetal gamma-globin gene expression in the setting of adult erythropoiesis both in vitro and in vivo. Studies in an adult-stage murine erythroleukemia (MEL) cell line demonstrated that retrovirus vector-mediated transduction of KLF11 could increase both the amount of expression from a basally active, but not from a overtly silenced, recombinant gamma-globin transgene, as well as the frequency of cells expressing this transgene. A similar pattern of gamma-globin gene induction was also observed both in vitro and in vivo following KLF11 transduction of bone marrow from mice containing a basally active gamma-globin transgene. These studies provide the first evidence that ectopic expression of a transcription factor can induce gamma-globin gene expression in vivo during adult erythropoiesis." @default.
• W2078498555 created "2016-06-24" @default.
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• W2078498555 date "2006-11-27" @default.
• W2078498555 modified "2023-10-10" @default.
• W2078498555 title "The transcription factor KLF11 can induce γ-globin gene expression in the setting of in vivo adult erythropoiesis" @default.
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• W2078498555 doi "https://doi.org/10.1002/jcb.21093" @default.
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