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- W2078498754 abstract "RATIONALE: Although majority of patients are now well controlled wiith inhaled corticosteroids, some asthmatics still require oral stroids either on daily or as needed basis.Evaluation of the effect of Risedronate sodium hydrate on osteoporosis was carried out in asthma and non-asthma patients requiring steroid therapy in one form or another METHODS: Patients whose biochemical bone resorption marker, serum cross-linked collagen N-peptides(serum NTx)was below 14nM BCE/L and/or the bone mineral density(BMD) below 80% young adult mean(YAM) employing digital image processing(DIP)were asked to join a follow up study to take Risedronate sodium hydrate for 8 to 48 weeks. Sixty patients finished the study,13 males and 47 females. Four dropped out,2 due to aggravation of original disease and 2 due to side effects. Twenty two had asthma, all on some form of steroids,while 38 was non-asthmatics, 28 without and 10 with steroids.The patients were grouped into those using oral steroids on daily basis(A),oral steroids only as needed(B),only on inhaled corticosteroid(C),and those without steroid(D) RESULTS: NTx level showed no correlations to any of the factors except age showing favorable response in younger age group upon taking Risedronate. However,when analyzed within female participants,it was found that those on oral steroid (group A+B)responded significantly better to Risedronate sodium hydrate than those on inhaled corticosteroids or those without any steroids(group C+D).(p value:0.029).None of the factors were found to correlate with the bone mineral density assessed by DIP CONCLUSIONS: Significant decrease in NTx after oral Risedronate in females requiring oral steroids suggest its advantage in severe female asthmatics on current oral corticosteorids." @default.
- W2078498754 created "2016-06-24" @default.
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- W2078498754 date "2005-02-01" @default.
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- W2078498754 title "The effect of Risedronate sodium hydrate (benet®) in patients with or without asthma, employing different doses of steroid" @default.
- W2078498754 doi "https://doi.org/10.1016/j.jaci.2004.12.853" @default.
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