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- W2078498873 abstract "5-methoxypsoralen (bergapten) has been used in the treatment of psoriasis and vitiligo, and as a sun tanning accelerator. While low plasma concentrations have previously been detected, there is no data on its dermatopharmacokinetics.Three rhesus monkeys were used as a model for human skin. [14C]-5-methoxypsoralen, as a parenteral excretion control, was injected in propylene glycol with an activity of 1.12 uCi/ml at a concentration of 80 mcg/ml and urine was collected at 4, 8, 12, 24h, and then daily for a total of 6 days. [14C]-5-methoxypsoralen was then applied topically in acetone with a dose of 1.19 mc (72 mcg) and urine was collected at 4 and 24h and then daily for a total of 7 days. The amount excreted was corrected for the previously determined parenteral excretion kinetics.Intramuscular [14C]-5-methoxypsoralen had an average of 71.87±7.77% of excretion and percutaneously applied [14C]-5-methoxypsoralen had an average of 58.4±11.8% of excretion.A high percentage of the administered 5-methoxypsoralen was absorbed. This provides a foundation of methodology to evaluate the efficacy of other delivery vehicles for 5-methoxypsoralen and serves as part of its dermatotoxic profile." @default.
- W2078498873 created "2016-06-24" @default.
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- W2078498873 date "2011-05-01" @default.
- W2078498873 modified "2023-09-26" @default.
- W2078498873 title "Percutaneous penetration of 5-methoxypsoralen in rhesus monkeys" @default.
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- W2078498873 doi "https://doi.org/10.1016/j.fct.2011.01.018" @default.
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