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- W2078499306 abstract "Neural type I membrane proteins Alcadein (Alcs) family, composed of Alca, Alcb and Alcg, are largely colocalized with APP in brain. The both Alc and APP are subject to coordinated metabolism. Processing of Alcs by APP a- and g-secretases secretes non-aggregative small peptide p3-Alc into cerebrospinal fluid (CSF) (Hata et al., J. Biol. Chem. [2009] 284, 36024). p3-Alca species with altered C-termini are increased in CSF of SAD patients, suggesting g-secretase malfunction in SAD patients without mutations on PS genes (Hata et al., Ann. Neurol. 2010). We developed several types of sandwich ELISA system to quantify blood p3-Alca levels and examined plasma p3-Alca levels of AD and non-AD subjects. With combinations of several types of antibodies specific to p3-Alca fragments, we constructed sELISA systems, which worked successfully to quantify p3-Alca levels in 100 mL of plasma. We examined the specificity and sensitivity of sELISA systems with synthetic p3-Alca and p3-Alcb peptides and plasma samples derived from normal volunteers. The sELISA systems specifically reacted to p3-Alca but not p3-Alcb, and could detect >40 pg/ mL of synthetic p3-Alca35. Level of plasma p3-Alca was significantly higher in sporadic AD subjects than in elderly age-matched non-AD controls. Interestingly the statistical difference was largely restricted to female subjects. Taken together our separate analysis for qualitative change of p3-Alca species in CSF of sporadic AD patients, quantitative alteration of p3-Alca in blood may involve in g-secretase malfunction characterized by AD, and may be useful for AD biomarker." @default.
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- W2078499306 date "2011-07-01" @default.
- W2078499306 modified "2023-10-06" @default.
- W2078499306 title "P3-188: Quantification of plasma p3-Alca level with sELISA systems" @default.
- W2078499306 doi "https://doi.org/10.1016/j.jalz.2011.05.1629" @default.
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