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- W2078501698 abstract "Abstract The entry of choline into cells of the segmental ganglia of the leech ( Hirudo medicinalis ) was studied in vitro using 3 H-choline. The weight of a fresh ganglion was found to be about 53 μg and its water content about 78 per cent. After 30 min of incubation the mannitol space was about 47 per cent and the inulin space about 35% of the total ganglion volume. The accumulation of 3 H-choline was considerably faster than that of mannitol or inulin. After 30 min of incubation the intracellular choline concentration calculated on the basis of the mannitol extracellular space was about 10 times higher than the labelled choline concentration in the medium. Paper chromatography showed that about 65 per cent of the total radioactivity inside the ganglion was still in the form of choline and about 25 per cent in the form of acetylcholine. At external choline concentrations ranging from 0.06 to 1 mM the choline entry obeyed the Michaelis-Menten kinetics. The maximum entry rate and the Michaelis constant calculated from these data were about 8 m-moles/30 min/1. of intracellular water and 1 mM, respectively. The choline entry decreased when tetramethylammonium or hemicholinium-3 was added to the incubating solution, tetramethylammonium had a stronger inhibitory effect than hemicholinium-3. Our results suggest that at the choline concentrations studied, the choline entry is mediated by a carrier and that a considerable portion of choline is transformed into acetylcholine." @default.
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- W2078501698 date "1974-09-01" @default.
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- W2078501698 title "Accumulation of choline by the segmental ganglia of the leech" @default.
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- W2078501698 doi "https://doi.org/10.1016/0006-2952(74)90182-8" @default.
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