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• W2078503271 abstract "Pseudomonas aeruginosa lipase is a 29-kDa protein that, following the determination of its crystal structure, was postulated to have a lid that stretched between residues 125 and 148. In this paper, using molecular dynamics simulations, we propose that there exists, in addition to the above-mentioned lid, a novel second lid in this lipase. We further show that the second lid, covering residues 210-222, acts as a triggering lid for the movement of the first. We also investigate the role of hydrophobicity in the movement of the lids and show that two residues, Phe214 and Ala217, play important roles in lid movement. To our knowledge, this is the first time that a double-lid movement of the type described in our manuscript has been presented to the scientific community. This work also elucidates the interplay of hydrophobic interactions in the dynamics, and hence the function, of an enzyme." @default.
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• W2078503271 date "2005-08-12" @default.
• W2078503271 modified "2023-10-17" @default.
• W2078503271 title "Evidence of a Double-Lid Movement in Pseudomonas aeruginosa Lipase: Insights from Molecular Dynamics Simulations" @default.
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• W2078503271 doi "https://doi.org/10.1371/journal.pcbi.0010028" @default.
• W2078503271 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1187864" @default.
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