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- W2078504091 abstract "Matrix pellets were produced combining microcrystalline waxes, pregelatinized starches and hydrolysed starches. Ibuprofen, sodium salicylate, benzoic acid, sodium benzoate and chloroquine phosphate were used as model drugs. Using a wax with a melting range between 68 and 72°C and increasing the wax concentration decreased the drug release rate. Pellets containing drum-dried corn starch failed to form matrix pellets. The slowest drug release was obtained for formulations containing waxy maltodextrin, releasing 95% of the incorporated ibuprofen after 48 h in vitro. Increasing the ibuprofen concentration decreased the drug release rate. Drug release was controlled by pore and matrix diffusion. The release of sodium salicylate and sodium benzoate from the wax-starch matrix pellets was characterised by an initial burst release followed by a block of the drug release." @default.
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- W2078504091 date "1996-05-01" @default.
- W2078504091 modified "2023-09-26" @default.
- W2078504091 title "Matrix pellets based on the combination of waxes, starches and maltodextrins" @default.
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- W2078504091 doi "https://doi.org/10.1016/0378-5173(95)04431-0" @default.
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