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• W2078505538 abstract "Aims To determine infant exposure to 6-thioguanine and 6-methylmercaptopurine nucleotides (6-TGN and 6-MMPN, respectively) during maternal use of azathioprine in breastfeeding. Methods Mother-infant pairs provided blood for determination of 6-TGN and 6-MMPN concentrations, and TPMT genotype. Results Four women taking azathioprine 1.2–2.1 mg kg−1 day−1 and their infants were studied. All had the wild-type TPMT genotype. Maternal 6-TGN and 6-MMPN concentrations ranged from 234 to 291 and 284 to 1178 pmol per 8 × 108 red blood cells, respectively, and were consistent with those associated with improved therapeutic outcomes. Neither 6-TGN nor 6-MMPN was detected in any of the infants, despite a sensitive assay. Conclusions The data suggest that azathioprine may be ‘safe’ during breastfeeding in patients with the wild-type TPMT genotype (∼90% of caucasian patients) taking ‘normal’ doses." @default.
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• W2078505538 date "2006-10-01" @default.
• W2078505538 modified "2023-09-23" @default.
• W2078505538 title "Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs" @default.
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• W2078505538 doi "https://doi.org/10.1111/j.1365-2125.2006.02639.x" @default.
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