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• W2078507841 abstract "This study shows for the first time that both the putatively selective oestrogen receptor alpha and oestrogen receptor beta agonists PPT (4,4',4-(4-propyl-[(1)H]-pyrazole-1,3,5-triyl) tris-phenol) and DPN (2,3-bis(4-hydroxyphenyl)-propionitrile) can acutely relax precontracted isolated rat mesenteric arteries at pharmacological (i.e. micro M) concentrations. When compared to responses observed to similar concentrations of 17beta-oestrogen obtained on the same tissues, PPT had a significantly greater vasodilatory effect, while DPN had a significantly smaller effect. All responses were rapid being complete within 5 min exposure time. Thus, both PPT and DPN can acutely relax isolated mesenteric arteries with the relative potency of PPT>17beta-oestrogen>DPN." @default.
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• W2078507841 date "2003-08-01" @default.
• W2078507841 modified "2023-10-14" @default.
• W2078507841 title "Acute effects of oestrogen receptor subtype-specific agonists on vascular contractility" @default.
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• W2078507841 doi "https://doi.org/10.1038/sj.bjp.0705368" @default.
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