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- W2078508742 abstract "Sarcoid is a generalized disease with fairly characteristic but nonspecific, noncaseating granulomas found most frequently in the hematopoietic tissues. Clinically it is usually manifested by a chronic course with fever and various combinations of lymphadenopathy, splenomegaly, and hepatomegaly. Leukopenia and reversal of the protein albumin-globulin ratio are frequent. A fairly characteristic diffuse lesion in the lung fields, hilar lymphadenopathy, and, less frequently, osteolytic lesions of the small bones of the hands and feet may be found on x-ray examination. A negative tuberculin reaction, even with old tuberculin in 1:10 dilution, and a positive Kveim reaction occur in almost all patients. Since numerous diseases may mimic sarcoid in one or more of these respects, it is necessary that one demonstrate as many of these phenomena as possible in order to make a definite diagnosis. More important and usually more difficult is the demonstration of the non-caseating granuloma. The usual method is" @default.
- W2078508742 created "2016-06-24" @default.
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- W2078508742 date "1952-06-21" @default.
- W2078508742 modified "2023-09-25" @default.
- W2078508742 title "SARCOID DIAGNOSED BY NEEDLE BIOPSY OF THE SPLEEN" @default.
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- W2078508742 doi "https://doi.org/10.1001/jama.1952.02930250030010" @default.
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