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- W2078510519 abstract "Abstract Immune intravenous gamma globulin (IVIG) and the disaccharides added to the preparations were evaluated for inhibition of natural killer (NK) cell activity. Natural killer cell activity was significantly reduced by incorporation of immune intravenous gamma globulin (IVIG) into an assay employing 51Cr-labeled K562 cells and effector lymphocytes from healthy adult donors. The inhibitory effect of the IVIG was directed against effector cells, including enriched fractions of large granular lymphocytes. Maltose and sucrose, additives to two of the IVIG preparations examined, also diminished NK activity but to a lesser degree than the immune globulins. Reconstitution experiments and the elimination of disaccharides from IVIG preparations indicated that the sugars do not contribute to the diminished NK activity seen in patients treated with IVIG. Clinical responses following intravenous therapy with IVIG may, therefore, be associated with an effect of the gamma globulin on NK activity." @default.
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- W2078510519 date "1987-10-01" @default.
- W2078510519 modified "2023-09-26" @default.
- W2078510519 title "Suppression of natural killer cell activity by preparations of intravenous immune globulin" @default.
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- W2078510519 doi "https://doi.org/10.1016/0888-0786(87)90043-6" @default.
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