Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078512506> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2078512506 endingPage "1130" @default.
- W2078512506 startingPage "1125" @default.
- W2078512506 abstract "Background The appearance of eosinophils is a hallmark sign of the allergic late-phase response (LPR). Eosinophil cationic protein (ECP), a readily measurable product released from activated eosinophils, has so far not been evaluated in the ocular LPR. Objective Two sets of trials were performed in order to investigate changes of local and systemic eosinophil activity and their possible link with symptoms and hyper-reactivity in the allergic LPR in the eye. Methods In the first experiment, ECP was analysed in tears and serum and the clinical reaction was evaluated during a 72-h time–course after a single, high-dose allergen challenge out of season in one eye of 15 pollen-sensitized volunteers. In a second experiment, the hypothesis of an increased clinical response to an allergen challenge in an eye that had been provoked with allergen 48h previously was tested in nine sensitized individuals. Results In the first experiment, symptoms at 10 min and 2, 4, 6, 8 and 24 h significantly exceeded base line scores of the challenged eyes. Tear ECP was significantly elevated in challenged eyes compared to contralateral eyes at 6, 8 and 24 h. In addition, symptoms and ECP release correlated significantly at the 24-h evaluation. Serum ECP remained unchanged throughout the study period. In the second experiment, conjunctival hyperreactivity 48h after an allergen challenge was not confirmed. Conclusion ECP secretion occurs in the experimental ocular LPR and is in part associated with the magnitude of the clinical reaction, which suggests a truly pathogenic role of the activated eosinophil in pollen-induced allergic conjunctivitis." @default.
- W2078512506 created "2016-06-24" @default.
- W2078512506 creator A5007738483 @default.
- W2078512506 creator A5009457161 @default.
- W2078512506 creator A5014449070 @default.
- W2078512506 date "1996-10-01" @default.
- W2078512506 modified "2023-09-23" @default.
- W2078512506 title "Sustained eosinophil cationic protein release into tears after a single high-dose conjunctival allergen challenge" @default.
- W2078512506 cites W1497022815 @default.
- W2078512506 cites W1982633250 @default.
- W2078512506 cites W1996154016 @default.
- W2078512506 cites W1996369191 @default.
- W2078512506 cites W1997103802 @default.
- W2078512506 cites W2001728531 @default.
- W2078512506 cites W2023680623 @default.
- W2078512506 cites W2030548240 @default.
- W2078512506 cites W2033148441 @default.
- W2078512506 cites W2033959129 @default.
- W2078512506 cites W2047202466 @default.
- W2078512506 cites W2048934597 @default.
- W2078512506 cites W2065519014 @default.
- W2078512506 cites W2065719831 @default.
- W2078512506 cites W2068306007 @default.
- W2078512506 cites W2070197559 @default.
- W2078512506 cites W2072892059 @default.
- W2078512506 cites W2076690017 @default.
- W2078512506 cites W2080502516 @default.
- W2078512506 cites W2120478235 @default.
- W2078512506 cites W2127326483 @default.
- W2078512506 cites W2155418062 @default.
- W2078512506 cites W2312870247 @default.
- W2078512506 doi "https://doi.org/10.1111/j.1365-2222.1996.tb00498.x" @default.
- W2078512506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8911697" @default.
- W2078512506 hasPublicationYear "1996" @default.
- W2078512506 type Work @default.
- W2078512506 sameAs 2078512506 @default.
- W2078512506 citedByCount "32" @default.
- W2078512506 countsByYear W20785125062013 @default.
- W2078512506 countsByYear W20785125062014 @default.
- W2078512506 countsByYear W20785125062016 @default.
- W2078512506 countsByYear W20785125062017 @default.
- W2078512506 countsByYear W20785125062019 @default.
- W2078512506 countsByYear W20785125062021 @default.
- W2078512506 countsByYear W20785125062022 @default.
- W2078512506 crossrefType "journal-article" @default.
- W2078512506 hasAuthorship W2078512506A5007738483 @default.
- W2078512506 hasAuthorship W2078512506A5009457161 @default.
- W2078512506 hasAuthorship W2078512506A5014449070 @default.
- W2078512506 hasConcept C203014093 @default.
- W2078512506 hasConcept C207480886 @default.
- W2078512506 hasConcept C2776042228 @default.
- W2078512506 hasConcept C2777037409 @default.
- W2078512506 hasConcept C2778275304 @default.
- W2078512506 hasConcept C2780510475 @default.
- W2078512506 hasConcept C2780870513 @default.
- W2078512506 hasConcept C71924100 @default.
- W2078512506 hasConcept C88675164 @default.
- W2078512506 hasConceptScore W2078512506C203014093 @default.
- W2078512506 hasConceptScore W2078512506C207480886 @default.
- W2078512506 hasConceptScore W2078512506C2776042228 @default.
- W2078512506 hasConceptScore W2078512506C2777037409 @default.
- W2078512506 hasConceptScore W2078512506C2778275304 @default.
- W2078512506 hasConceptScore W2078512506C2780510475 @default.
- W2078512506 hasConceptScore W2078512506C2780870513 @default.
- W2078512506 hasConceptScore W2078512506C71924100 @default.
- W2078512506 hasConceptScore W2078512506C88675164 @default.
- W2078512506 hasIssue "10" @default.
- W2078512506 hasLocation W20785125061 @default.
- W2078512506 hasLocation W20785125062 @default.
- W2078512506 hasOpenAccess W2078512506 @default.
- W2078512506 hasPrimaryLocation W20785125061 @default.
- W2078512506 hasRelatedWork W1493367785 @default.
- W2078512506 hasRelatedWork W2004539066 @default.
- W2078512506 hasRelatedWork W2024667098 @default.
- W2078512506 hasRelatedWork W2068306007 @default.
- W2078512506 hasRelatedWork W2075537437 @default.
- W2078512506 hasRelatedWork W2101823334 @default.
- W2078512506 hasRelatedWork W2127326483 @default.
- W2078512506 hasRelatedWork W2132158328 @default.
- W2078512506 hasRelatedWork W2157547519 @default.
- W2078512506 hasRelatedWork W2611818413 @default.
- W2078512506 hasVolume "26" @default.
- W2078512506 isParatext "false" @default.
- W2078512506 isRetracted "false" @default.
- W2078512506 magId "2078512506" @default.
- W2078512506 workType "article" @default.