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- W2078512733 abstract "T lymphocytes respond to small peptides in the context of major histocompatibility molecules and a host of other cell-surface proteins on antigen-presenting cells. By design, therefore, T-cell responses are dependent on the efficient and accurate processing of both foreign and self peptides by antigen-presenting cells. This review examines the functions of T cells that may be specific for self peptides processed and presented under less than ideal conditions or outside the normal pathways of antigen processing. Do these T cells survive selection events and remain in the repertoire of normal lymphocytes? Moreover, can these cells become activated and are they important in the pathogenesis of autoimmunity?" @default.
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- W2078512733 date "1994-12-01" @default.
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- W2078512733 title "The expression of self antigenic determinants: implications for tolerance and autoimmunity" @default.
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- W2078512733 doi "https://doi.org/10.1016/0952-7915(94)90008-6" @default.
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