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- W2078518197 abstract "Background Impaired social behaviour, partly related to altered perception of emotions, is commonly reported in HD patients. Over the past few years the role of oxytocin (OT) as social hormone has been proposed and it is supported by the improvement of recognition of the expression of the faces after administration of intranasal OT. Aims To investigate social cognition in HD and to evaluate the role of OT as social hormone. Methods 8 symptomatic HD (stage II S&F) and 9 controls, matched for age and educational level were investigated for social cognition by means of an extensive battery of neuropsychological tests. The basal levels of OT were analysed in the whole study group and searching for relationship between blood levels and social cognition. Results HD patients showed lower performances at Faux pas, Strange Stories test and in recognising face expression evaluated by KDEF scale (p Conclusions The present study, albeit severely limited by sample size, shows an extensive impairment of social cognition in HD population. The impairment mainly involves the perception of emotions, dependent both on the cognitive impairment and on basal levels of OT. Our finding that social cognition, at least as regards to perception of emotions, may be in part related to OT might support the hypothesis of hypothalamic involvement in HD." @default.
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- W2078518197 date "2014-09-01" @default.
- W2078518197 modified "2023-09-27" @default.
- W2078518197 title "B41 Social Cognition And Oxytocin In Huntington's Disease: Evidences From A Preliminary Study" @default.
- W2078518197 doi "https://doi.org/10.1136/jnnp-2014-309032.69" @default.
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