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- W2078522296 abstract "<h2>Abstract</h2> The current study investigates the effect of megestrol acetate, a synthetic progestin, on the activity of interleukin-1. Murine thymocytes were suspended <i>in vitro</i> and stimulated with varying concentrations of interleukin-1. [<sup>3</sup>H]Thymidine uptake was observed as an index of thymocyte proliferation. A dose-dependent increase in [<sup>3</sup>H]thymidine uptake was observed with increasing concentrations of interleukin-1. When megestrol acetate was added to the solution, a marked suppressive effect was observed. Higher doses of megestrol acetate had a greater suppressive effect on thymocyte proliferation. Additional investigation is required to further delineate the potential systemic effects of megestrol acetate." @default.
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- W2078522296 date "1991-12-01" @default.
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- W2078522296 title "The effect of megestrol acetate on interleukin-1 activity" @default.
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- W2078522296 doi "https://doi.org/10.1016/0090-8258(91)90031-y" @default.
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