Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078525079> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2078525079 endingPage "593" @default.
- W2078525079 startingPage "586" @default.
- W2078525079 abstract "l-Canavanine (CAV) is a potent L-arginine antagonist, produced by legumes such as the jack bean, Canavalla ensiformis. CAV is cytotoxic to MIA PaCa-2 human pancreatic cancer cells. We sought to determine whether CAV's efficacy as an anticancer agent might be increased in combination with 5-fluorouracil (5-FU), a pyrimidine antimetabolite with activity against solid tumors. Using optimal conditions for the expression of CAV's cytotoxicity against MIA PaCa-2 cells, CAV was more cytotoxic to the cells than 5-FU. The combination of both drugs at a fixed molar ratio of 1:1 exhibited synergistic effects in the cells as determined by combination index analysis. The combination of 5-FU:CAV was tested at a ratio of 5:1 and exhibited antagonism at lower effect levels, additivity at 50% effect levels and slight synergism at higher effect levels. A 10:1 combination of both drugs (5-FU:CAV) exhibited antagonistic effects at all levels. When the drugs were combined at a molar ratio of 20:1, increased antagonism was observed. When CAV (1.0 or 2.0 g/kg daily) and/or 5-FU (35 mg/kg daily) was administered to colonic tumor-bearing rats for five consecutive days, the antitumor activity of the drug combination was significantly greater than the combined effects of either drug alone. However, the body weight loss experienced by CAV-treated rats was increased in those rats exposed to a combination of both drugs. These studies using different tumors provide in vitro and in vivo evidence that combination therapy offers a viable means of improving CAV's intrinsic efficacy while decreasing the concentration of 5-FU required to produce the same cytotoxic effect. On the other hand, greater success is needed in further reducing body weight loss. Current efforts at CAV analog development are focusing on ways to amplify its antineoplastic activity while reducing significant body weight loss in order to produce a clinically useful therapeutic agent for the treatment of human pancreatic cancer." @default.
- W2078525079 created "2016-06-24" @default.
- W2078525079 creator A5013836099 @default.
- W2078525079 creator A5033410568 @default.
- W2078525079 creator A5038307470 @default.
- W2078525079 creator A5055127852 @default.
- W2078525079 creator A5064337262 @default.
- W2078525079 creator A5083049265 @default.
- W2078525079 creator A5087372115 @default.
- W2078525079 date "1995-08-01" @default.
- W2078525079 modified "2023-10-17" @default.
- W2078525079 title "Combination therapy with 5-fluorouracil and L-canavanine" @default.
- W2078525079 doi "https://doi.org/10.1097/00001813-199508000-00012" @default.
- W2078525079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7579563" @default.
- W2078525079 hasPublicationYear "1995" @default.
- W2078525079 type Work @default.
- W2078525079 sameAs 2078525079 @default.
- W2078525079 citedByCount "44" @default.
- W2078525079 countsByYear W20785250792012 @default.
- W2078525079 countsByYear W20785250792013 @default.
- W2078525079 countsByYear W20785250792014 @default.
- W2078525079 countsByYear W20785250792015 @default.
- W2078525079 countsByYear W20785250792016 @default.
- W2078525079 countsByYear W20785250792017 @default.
- W2078525079 countsByYear W20785250792018 @default.
- W2078525079 countsByYear W20785250792021 @default.
- W2078525079 countsByYear W20785250792022 @default.
- W2078525079 countsByYear W20785250792023 @default.
- W2078525079 crossrefType "journal-article" @default.
- W2078525079 hasAuthorship W2078525079A5013836099 @default.
- W2078525079 hasAuthorship W2078525079A5033410568 @default.
- W2078525079 hasAuthorship W2078525079A5038307470 @default.
- W2078525079 hasAuthorship W2078525079A5055127852 @default.
- W2078525079 hasAuthorship W2078525079A5064337262 @default.
- W2078525079 hasAuthorship W2078525079A5083049265 @default.
- W2078525079 hasAuthorship W2078525079A5087372115 @default.
- W2078525079 hasConcept C109316439 @default.
- W2078525079 hasConcept C121608353 @default.
- W2078525079 hasConcept C126322002 @default.
- W2078525079 hasConcept C150903083 @default.
- W2078525079 hasConcept C154317977 @default.
- W2078525079 hasConcept C170493617 @default.
- W2078525079 hasConcept C185592680 @default.
- W2078525079 hasConcept C202751555 @default.
- W2078525079 hasConcept C207001950 @default.
- W2078525079 hasConcept C2776694085 @default.
- W2078525079 hasConcept C2776999253 @default.
- W2078525079 hasConcept C2777383412 @default.
- W2078525079 hasConcept C2777468819 @default.
- W2078525079 hasConcept C2780210213 @default.
- W2078525079 hasConcept C2780258809 @default.
- W2078525079 hasConcept C515207424 @default.
- W2078525079 hasConcept C55493867 @default.
- W2078525079 hasConcept C71924100 @default.
- W2078525079 hasConcept C86803240 @default.
- W2078525079 hasConcept C98274493 @default.
- W2078525079 hasConceptScore W2078525079C109316439 @default.
- W2078525079 hasConceptScore W2078525079C121608353 @default.
- W2078525079 hasConceptScore W2078525079C126322002 @default.
- W2078525079 hasConceptScore W2078525079C150903083 @default.
- W2078525079 hasConceptScore W2078525079C154317977 @default.
- W2078525079 hasConceptScore W2078525079C170493617 @default.
- W2078525079 hasConceptScore W2078525079C185592680 @default.
- W2078525079 hasConceptScore W2078525079C202751555 @default.
- W2078525079 hasConceptScore W2078525079C207001950 @default.
- W2078525079 hasConceptScore W2078525079C2776694085 @default.
- W2078525079 hasConceptScore W2078525079C2776999253 @default.
- W2078525079 hasConceptScore W2078525079C2777383412 @default.
- W2078525079 hasConceptScore W2078525079C2777468819 @default.
- W2078525079 hasConceptScore W2078525079C2780210213 @default.
- W2078525079 hasConceptScore W2078525079C2780258809 @default.
- W2078525079 hasConceptScore W2078525079C515207424 @default.
- W2078525079 hasConceptScore W2078525079C55493867 @default.
- W2078525079 hasConceptScore W2078525079C71924100 @default.
- W2078525079 hasConceptScore W2078525079C86803240 @default.
- W2078525079 hasConceptScore W2078525079C98274493 @default.
- W2078525079 hasIssue "4" @default.
- W2078525079 hasLocation W20785250791 @default.
- W2078525079 hasLocation W20785250792 @default.
- W2078525079 hasOpenAccess W2078525079 @default.
- W2078525079 hasPrimaryLocation W20785250791 @default.
- W2078525079 hasRelatedWork W1965851372 @default.
- W2078525079 hasRelatedWork W2094153719 @default.
- W2078525079 hasRelatedWork W2115579238 @default.
- W2078525079 hasRelatedWork W2126322332 @default.
- W2078525079 hasRelatedWork W2596055884 @default.
- W2078525079 hasRelatedWork W2885862304 @default.
- W2078525079 hasRelatedWork W3031244932 @default.
- W2078525079 hasRelatedWork W3031675857 @default.
- W2078525079 hasRelatedWork W4205828341 @default.
- W2078525079 hasRelatedWork W4281720666 @default.
- W2078525079 hasVolume "6" @default.
- W2078525079 isParatext "false" @default.
- W2078525079 isRetracted "false" @default.
- W2078525079 magId "2078525079" @default.
- W2078525079 workType "article" @default.